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Article title matches
- Category:Fviia activation (47 bytes)
1: List of pages with the keyword Fviia activation - Category:Fviia and souluble tissue factor (63 bytes)
1: List of pages with the keyword Fviia and souluble tissue factor - Image:FVIIa-TF FX.jpg (36 bytes)
1: Complex of TF-FVIIa and FX substrate - FVIIa (25 bytes)
- Category:Fviia (36 bytes)
1: List of pages with the keyword Fviia - Image:Fviia.pdb (0 bytes)
Page text matches
- 2c4f (5,766 bytes)
7: ...nd=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4f ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c4f ConSurf].
26: ...hrombotic drugs. A fluoropyridine-based series of FVIIa/TF inhibitors was discovered which utilized a dii...
32: <div class="pdbe-citations 2c4f" style="background-color:#fffaf0;... - 4isi (4,814 bytes)
7: ...PYRAZINE-6-CARBOXAMIDE'>1GG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4isi ProSAT]</span></td></tr>
16: ..., S2 and S3 pockets. Compound 9b showed excellent FVIIa potency, good selectivity against FIXa, Xa, XIa a...
18: ...c pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.,Zhang X, Glunz PW, Jiang W, Schmitt A...
22: <div class="pdbe-citations 4isi" style="background-color:#fffaf0;... - 1bf9 (5,983 bytes)
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bf9 ProSAT]</span></td></tr>
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bf9 ConSurf].
25: ...is responsible for the increased affinity of FVII/FVIIa for TF.
31: <div class="pdbe-citations 1bf9" style="background-color:#fffaf0;... - 1f7e (6,029 bytes)
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7e ProSAT]</span></td></tr>
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f7e ConSurf].
25: ...ain, it may affect the interaction of full-length FVIIa with TF by influencing its Ca2+-binding affinity.
31: <div class="pdbe-citations 1f7e" style="background-color:#fffaf0;... - 1f7m (6,032 bytes)
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f7m ProSAT]</span></td></tr>
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f7m ConSurf].
25: ...ain, it may affect the interaction of full-length FVIIa with TF by influencing its Ca2+-binding affinity.
31: <div class="pdbe-citations 1f7m" style="background-color:#fffaf0;... - 1ff7 (6,224 bytes)
7: ...<td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ff7 ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ff7 ConSurf].
26: ...ain, it may affect the interaction of full-length FVIIa with TF by influencing its Ca2+-binding affinity.
32: <div class="pdbe-citations 1ff7" style="background-color:#fffaf0;... - 1ffm (6,227 bytes)
7: ...<td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ffm ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ffm ConSurf].
26: ...ain, it may affect the interaction of full-length FVIIa with TF by influencing its Ca2+-binding affinity.
32: <div class="pdbe-citations 1ffm" style="background-color:#fffaf0;... - 1jbu (6,611 bytes)
7: ...ligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbu ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jbu ConSurf].
26: ...TF-mediated allosteric control of the activity of FVIIa can be rationalized. The reregistering beta stran...
32: <div class="pdbe-citations 1jbu" style="background-color:#fffaf0;... - 4ish (4,759 bytes)
7: ...ENYL-4-CARBOXYLIC+ACID'>1GE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ish ProSAT]</span></td></tr>
16: ...model. A crystal structure of BMS-593214 bound to FVIIa highlights key contacts with Asp 189, Lys 192, an...
18: ...cale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.,Priestley ES, De Lucca I, Zhou J, Zhou...
22: <div class="pdbe-citations 4ish" style="background-color:#fffaf0;... - 1wqv (6,084 bytes)
7: ...and=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=PSM:N-[DIHYDROXY(PROPYL)-LAMBDA~4~-SULFANYL...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wqv ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wqv ConSurf].
26: ...ture-based drug design of specific inhibitors for FVIIa/TF.
32: <div class="pdbe-citations 1wqv" style="background-color:#fffaf0;... - 1wss (6,530 bytes)
7: ...-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wss ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wss ConSurf].
26: ...ture-based drug design of specific inhibitors for FVIIa/TF.
32: <div class="pdbe-citations 1wss" style="background-color:#fffaf0;... - 1wtg (6,448 bytes)
7: ...-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wtg ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wtg ConSurf].
26: ...ortant role in achieving selective inhibition for FVIIa/TF.
32: <div class="pdbe-citations 1wtg" style="background-color:#fffaf0;... - 1wun (6,281 bytes)
7: ...and=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=P5B:N-(ETHYLSULFONYL)TRYPTOPHYL-N~1~-{4-[AM...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wun ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wun ConSurf].
26: ...d with Gln217, with a unique bent conformation in FVIIa/TF accompanied by conformational changes of the i...
32: <div class="pdbe-citations 1wun" style="background-color:#fffaf0;... - 1wv7 (6,307 bytes)
7: ...-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wv7 ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wv7 ConSurf].
26: ...d with Gln217, with a unique bent conformation in FVIIa/TF accompanied by conformational changes of the i...
32: <div class="pdbe-citations 1wv7" style="background-color:#fffaf0;... - 1ygc (6,745 bytes)
7: ...dbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ygc ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ygc ConSurf].
26: ...ure revealed a novel, nonstandard conformation of FVIIa active site in the region of the oxyanion hole, a...
32: <div class="pdbe-citations 1ygc" style="background-color:#fffaf0;... - 1zr0 (4,943 bytes)
7: ...<td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zr0 ProSAT]</span></td></tr>
20: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zr0 ConSurf].
24: ... electrostatic interactions are weak, whereas for FVIIa, hydrophobic interactions are missing, and electr...
30: <div class="pdbe-citations 1zr0" style="background-color:#fffaf0;... - 2a2q (7,040 bytes)
7: ...BZ:P-AMINO+BENZAMIDINE'>PBZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2q ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2q ConSurf].
26: ...hole is unusual and has biologic implications for FVIIa macromolecular substrate specificity and catalysi...
32: <div class="pdbe-citations 2a2q" style="background-color:#fffaf0;... - 2aei (5,636 bytes)
7: ...and=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aei ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aei ConSurf].
26: ...X-ray crystal structure of a fluoropyridine-based FVIIa/TF inhibitor bound in the active site of the enzy...
32: <div class="pdbe-citations 2aei" style="background-color:#fffaf0;... - 2aer (7,064 bytes)
7: ...pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aer ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aer ConSurf].
26: ...hole is unusual and has biologic implications for FVIIa macromolecular substrate specificity and catalysi...
32: <div class="pdbe-citations 2aer" style="background-color:#fffaf0;... - 2b7d (5,943 bytes)
7: ...<td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1B:(2R)-2-[5-(5-CARBAMIMIDOYL-1H-BENZOIMID...
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7d ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b7d ConSurf].
26: ...y selective and potent factor VIIa-tissue factor (fVIIa.TF) complex inhibitors were generated through str...
32: <div class="pdbe-citations 2b7d" style="background-color:#fffaf0;...
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