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Category:Janus kinase (43 bytes)
1: List of pages with the keyword Janus kinase
Janus kinase (2,095 bytes)
1: ...ne='54/543313/Cv/1' caption='JAK2 kinase domain complex with inhibitor thienopyridine [[3tjc]]'>
4: ...erleukin 2,4,7,9,15,21). '''TYK2''' is a component of type I and type III interferon signaling...
9: ...autoimmune diseases and transplant rejection<ref>PMID:23532440</ref>.
12: ...7</ref>. Mutations in Jak3 are associated with immune deficiency.
15: ...ATP-binding pocket<ref>PMID:22087750</ref>. Water molecules shown as red spheres.
Category:Janus, B.M (41 bytes)
1: List of pages with the keyword Janus, B.M
Category:Janus kinase 2 (45 bytes)
1: List of pages with the keyword Janus kinase 2
Category:Janus protein kinase (51 bytes)
1: List of pages with the keyword Janus protein kinase
Category:Janus, B M (41 bytes)
1: List of pages with the keyword Janus, B M
Category:Janus BM (39 bytes)
1: List of pages with the keyword Janus BM
Janus kinase 3D structures (4,941 bytes)
1: == 3D Structures of Janus kinase ==
3: Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
8: *''JAK1 kinase or JH1 domain residues 869-1153''
10: ...5]] - hJAK1 kinase domain + PTyr + inhibitor - human 
11: **[[5khw]] – hJAK1 kinase domain + PTyr + ADP

Page text matches

8ewy (4,114 bytes)
2: ... complexed with cytokine receptor intracellular domain==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=8EWY FirstGlance]. 
6: .../td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.5&#8491;</t...
7: ...e='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</sce...
8: ...wy RCSB], [https://www.ebi.ac.uk/pdbsum/8ewy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
1cgh (4,806 bytes)
2: ==Human cathepsin G==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1CGH FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...HYDROXY(OXIDO)PHOSPHANYL]-2-PHENYLETHYL}-L-PROLINAMIDE'>1ZG</scene></td></tr>
8: ...gh RCSB], [https://www.ebi.ac.uk/pdbsum/1cgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
1igr (8,140 bytes)
2: ==Type 1 Insulin-like growth factor receptor (DOMAINS 1-3)==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1IGR FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr...
8: ...gr RCSB], [https://www.ebi.ac.uk/pdbsum/1igr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
1jqh (8,055 bytes)
2: ==IGF-1 receptor kinase domain==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1JQH FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...'pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr...
8: ...qh RCSB], [https://www.ebi.ac.uk/pdbsum/1jqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
1k3a (7,805 bytes)
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1K3A FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...HONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></t...
8: ...3a RCSB], [https://www.ebi.ac.uk/pdbsum/1k3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
11: ...reased plasma IGF1.<ref>PMID:14657428</ref> <ref>PMID:15928254</ref>
3zep (5,553 bytes)
2: ==Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibit...
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=3ZEP FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...me='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></t...
8: ...ep RCSB], [https://www.ebi.ac.uk/pdbsum/3zep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
1m7n (5,847 bytes)
2: ...PO Insulin-like Growth Factor-1 Receptor Kinase Domain==
3: ...on load='1m7n' size='340' side='right'caption='[[1m7n]], [[Resolution|resolution]] 2.70&Aring;' scene...
5: .../b> use [https://proteopedia.org/fgij/fg.htm?mol=1M7N FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...ttps://prosat.h-its.org/prosat/prosatexe?pdbcode=1m7n ProSAT]</td></tr>
1p4o (5,923 bytes)
2: ==Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution.==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1P4O FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...4o RCSB], [https://www.ebi.ac.uk/pdbsum/1p4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
10: ...reased plasma IGF1.<ref>PMID:14657428</ref> <ref>PMID:15928254</ref>
1sav (5,569 bytes)
2: ==HUMAN ANNEXIN V WITH PROLINE SUBSTITUTION BY THIOPROL...
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1SAV FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...e='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRS:THIOPROLINE'>PRS</scene></td></tr...
8: ...av RCSB], [https://www.ebi.ac.uk/pdbsum/1sav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
1yvj (6,790 bytes)
2: ...=Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1YVJ FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...-DIMERCAPTOBUTANE-2,3-DIOL'>DTV</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></t...
8: ...vj RCSB], [https://www.ebi.ac.uk/pdbsum/1yvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
7ll4 (1,692 bytes)
2: ...solution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-114.==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=7LL4 FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...piperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitr...
8: ...l4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ll4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
7ll5 (1,738 bytes)
2: ...solution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=7LL5 FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...piperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitr...
8: ...l5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ll5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
2b7a (9,129 bytes)
2: ... Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=2B7A FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...Z[4,5-F]ISOQUINOLINE-7-ONE'>IZA</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></t...
8: ...7a RCSB], [https://www.ebi.ac.uk/pdbsum/2b7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
2oj9 (7,111 bytes)
2: ...ure of IGF-1R kinase domain complexed with a benzimidazole inhibitor==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=2OJ9 FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE'>BMI</scene></td></tr>
8: ...j9 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
4jia (7,384 bytes)
2: ==JAK2 kinase (JH1 domain) in complex with compound 9==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=4JIA FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...me='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></t...
8: ...ia RCSB], [https://www.ebi.ac.uk/pdbsum/4jia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
1d6r (2,521 bytes)
2: ... TRYPSIN AT 2.3 A RESOLUTION. STRUCTURAL BASIS OF JANUS-FACED SERINE PROTEASE INHIBITOR SPECIFICITY==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1D6R FirstGlance]. 
6: ...odels|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resoluti...
7: ...6r RCSB], [https://www.ebi.ac.uk/pdbsum/1d6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
10: [https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
1dl0 (2,961 bytes)
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=1DL0 FirstGlance]. 
6: ...class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
7: ...l0 RCSB], [https://www.ebi.ac.uk/pdbsum/1dl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
10: ...MID:17141372</ref> <ref>PMID:18625007</ref> <ref>PMID:18986214</ref>
12: == Publication Abstract from PubMed ==
3rpb (3,969 bytes)
2: ...BPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=3RPB FirstGlance]. 
6: ...td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
7: ...pb RCSB], [https://www.ebi.ac.uk/pdbsum/3rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
10: ...lease by regulating membrane flow in the nerve terminal.
8yyu (7,571 bytes)
2: ==A tetrameric STAT1-DNA complex==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=8YYU FirstGlance]. 
6: .../td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.84&#8491;</...
7: .../td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></t...
8: ...yu RCSB], [https://www.ebi.ac.uk/pdbsum/8yyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...
8yyv (7,568 bytes)
2: ==A dimeric STAT1-DNA complex==
5: ...ents use [https://proteopedia.org/fgij/fg.htm?mol=8YYV FirstGlance]. 
6: .../td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.07&#8491;</...
7: .../td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></t...
8: ...yv RCSB], [https://www.ebi.ac.uk/pdbsum/8yyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbc...

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