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- Vasodilator-stimulated phosphoprotein (1,779 bytes)
1: ... caption='Human VASP (dark olive) complex with α-actin (cyan), profilin-1 (green), ATP (stick model) and...
3: ...hem to focal adhesion cell membranes. VASP is an actin- and profilin-binding protein<ref>PMID:16197368</...
4: ...rb edge against capping and increases the rate of actin polymerization in the presence of capping protein...
5: For more details see [[Group:MUZIC:Mena_VASP]].
11: ...odel) and Ca+2 ion</scene> ([[2pbd]]). VASP binds actin with a <scene name='50/508423/Cv/10'>poly-Pro sit... - Muscle LIM protein (1,054 bytes)
3: ...PMID:9234731</ref>. For more details see [[Group:MUZIC:MLP]] and [[MLP]]. - Group:MUZIC:actinin2 (7,211 bytes)
2: ===α-actinin-2===
4: ...[[http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Interactome]], members of different protein class...
6: ... protein α-actinin skeletal muscle isoform 2 (α-actinin-2) has a pivotal role in the formation and inte...
8: ...regulating cell shape and cell motility, while α-actinin-4 are related to the cytoskeleton playing an es...
12: ...[[http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Titin]] mediated by ABD domain and EF-hand domain... - Proteopedia:Table of Contents (3,885 bytes)
51: ** [[Actin]]
97: ** [[Group:MUZIC|Muscle sarcomere: Z-Disk]] - F-actin capping protein (847 bytes)
1: ...0' side='right' scene='50/508421/Cv/1' caption='F-actin capping protein α (cyan) and β subunits (magent...
4: ...own as red sphesres. For more details see [[Group:MUZIC:CapZ]].
7: ==3D structures of F-actin capping protein==
9: [[F-actin capping protein 3D structures]] - Filamin (1,187 bytes)
1: ...0' side='right' scene='' caption='Human Filamin B actin-binding domain complex with sulfate and carbonate...
7: ...has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membra...
10: For more details on filamin C see [[Group:MUZIC:FilaminC]]. - Titin (7,066 bytes)
5: *[[Group:MUZIC:Titin]].
15: ...] between the [http://en.wikipedia.org/wiki/Actin actin] filaments and to re-establish the unstreched mod...
17: ...filament is connected mechanically over the alpha-actinin with the z-disk. This bond is relatively weak a... - Actinin (1,334 bytes)
1: ...ide='right' scene='43/430017/Cv/2' caption='Alpha-actinin-1 [[2eyi]]'>
6: ...f actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:<br />
7: * '''ACTN1''' encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.<br />
8: ...les. For more details on ACTN2 see [[Group:MUZIC:actinin2]].<br />
9: * '''ACTN3''' encodes aA3 which anchors actin at the muscle Z-disk.<br /> - Plectin (1,952 bytes)
1: ...re load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '>
3: ...940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprisin...
5: For more details see [[Group:MUZIC:Plectin]].
15: [[1mb8]], [[4q59]] – hPCN actin-binding domain 59-293 – human<br />
23: [[3f7p]], [[4q58]] - hPCN actin-binding domain + integrin β4 residues 1126-1370<... - User:Ritika Sethi/workbench (5,398 bytes)
12: ...unit is composed of an α actinin like N terminal actin binding domain (ABD) made up of 2 calponin homolo...
50: ...1975 as one of the most potent crosslinkers of F- actin <ref> PMID 124734 </ref> , major efforts have bee...
53: • Cross linking actin filaments to form Orthogonal branched networks
55: • Physically linking actin cytoskeleton to the membrane
59: • Serving as scaffold for various interacting proteins which indicates its role in signalling - Group:MUZIC (5,320 bytes)
4: .../ref>] and nebulin, which spans the length of the actin filaments [reviewed in <ref name="r1">PMID:121422...
13: ... grey). Nebulin is shown in grey, wrapping around actin filaments. The Z-disc and the M-band comprise add...
16: ...required for muscle contraction and comprises the actin, titin, and nebulin filaments.
24: ...nts (grey) interconnected by several layers of α-actinin (green and red) forming an overlapping zigzag l...
35: ...r machinery for muscle contraction comprising the actin, titin, and nebulin filaments <ref>PMID:22028589<... - Group:MUZIC:FilaminC (6,643 bytes)
10: ...unit is composed of an α-actinin like N terminal actin binding domain (ABD) made up of 2 calponin homolo...
57: ...1975 as one of the most potent crosslinkers of F- actin <ref> PMID 124734 </ref> , major efforts have bee...
60: • Cross linking actin filaments to form Orthogonal branched networks
62: • Physically linking actin cytoskeleton to the membrane
66: • Serving as scaffold for various interacting proteins which indicates its role in signalling - User:Euripides Ribeiro/workbench/alpha-actinin (7,551 bytes)
1: =α-actinin-2=
3: ...[[http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Interactome]], members of different protein class...
5: The protein α-actinin skeletal muscle isoform 2 (ACTN2) is one the mo...
7: ...ners). It is worth pointing out that the other α-actinin non-muscles isoforms (1 and 4) are calcium-depe...
11: ...[[http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Titin]] mediated by ABD domain and EF-hand domain... - Group:MUZIC:Interactome (1,752 bytes)
3: rect 157 261 199 284 [[Group:MUZIC:ALP]]
4: rect 449 218 504 243 [[Group:MUZIC:Actin]]
5: rect 181 55 257 75 [[Group:MUZIC:ANKRD2]]
6: rect 123 309 197 330 [[Group:MUZIC:CARP]]
7: rect 505 88 596 115 [[Group:MUZIC:Calcineurin]] - PDZ and LIM domain protein (2,438 bytes)
3: ...ils on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]].
5: ...ent at the cytoskeleton. For details see [[Group:MUZIC:ALP]].<br />
7: *'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br />
23: **[[2pkt]] – hPDLIM + α-actinin C terminal - human<br />
41: **[[2v1w]] – hPDLIM + α-actinin C terminal <br /> - Nebulin (997 bytes)
3: ... an actin-binding protein which can bind upto 200 actin molecules. Nebulin length is proportional to the...
5: For more details see [[Group:MUZIC:Nebulin]].
17: [[7qim]] – mNebulin + actin – Cryo EM<br />
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