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  1. 1j5a (5,018 bytes)
    11: ...modified macrolide azithromycin, which blocks the tunnel.[HAMAP-Rule:MF_01328_B]
    24: ...iotics chloramphenicol, clindamycin and the three macrolides erythromycin, clarithromycin and roxithromycin. W...
  2. 1k8a (4,567 bytes)
    24: ...nce render the binding site less complementary to macrolides.
  3. 1k9m (4,558 bytes)
    24: ...nce render the binding site less complementary to macrolides.
  4. 1kd1 (4,566 bytes)
    24: ...nce render the binding site less complementary to macrolides.
  5. 1nwx (4,030 bytes)
    24: ...ecules of azithromycin bind simultaneously to the tunnel. The additional molecule also interacts with two ...
  6. 1nwy (4,272 bytes)
    11: ... the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Forms the main doc...
    24: ...ecules of azithromycin bind simultaneously to the tunnel. The additional molecule also interacts with two ...
  7. 1ond (5,289 bytes)
    11: ...airpin is displaced, which severely restricts the tunnel. This and experiments in E.coli have led to the s...
    24: ...f mutations that alleviate elongation arrest, the tunnel motion could be correlated with sequence discrimi...
    26: Structural insight into the role of the ribosomal tunnel in cellular regulation.,Berisio R, Schluenzen F, ...
  8. 1sm1 (6,181 bytes)
    24: ...itory mechanism, namely blockage of the ribosomal tunnel. Dalfopristin, the corresponding streptogramin A ...
  9. 1yij (5,072 bytes)
    24: ... L22 shows a change in the L22 structure and exit tunnel shape that illuminates its macrolide resistance p...
  10. 1yit (5,327 bytes)
    24: ... L22 shows a change in the L22 structure and exit tunnel shape that illuminates its macrolide resistance p...
  11. 1yjw (5,419 bytes)
    11: ...o which it binds. Located at the polypeptide exit tunnel on the outside of the subunit.[HAMAP-Rule:MF_0037...
    24: ... L22 shows a change in the L22 structure and exit tunnel shape that illuminates its macrolide resistance p...
  12. 1p9x (2,647 bytes)
    12: ...23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced ac...
  13. User:Wayne Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin (5,141 bytes)
    14: ..._Azithromycin/1m1kazo/4'>Azithromycin sits in the tunnel where it would occlude the nascent polypeptide ch...
    16: ... Ribosomal Subunit of Haloarcula#Polypeptide Exit Tunnel:|here]]'''.
  14. 8fc6 (5,287 bytes)
    12: ...ar mechanism of overcoming Erm-type resistance by macrolides acting together with hygromycin A. Altogether our...
    14: ...echanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.,Chen CW, Leime...
  15. 8fc5 (5,734 bytes)
    14: ...ar mechanism of overcoming Erm-type resistance by macrolides acting together with hygromycin A. Altogether our...
    16: ...echanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.,Chen CW, Leime...
  16. 8fc1 (5,516 bytes)
    14: ...ar mechanism of overcoming Erm-type resistance by macrolides acting together with hygromycin A. Altogether our...
    16: ...echanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.,Chen CW, Leime...
  17. 8fc2 (5,453 bytes)
    14: ...ar mechanism of overcoming Erm-type resistance by macrolides acting together with hygromycin A. Altogether our...
    16: ...echanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.,Chen CW, Leime...
  18. 8fc3 (5,665 bytes)
    14: ...ar mechanism of overcoming Erm-type resistance by macrolides acting together with hygromycin A. Altogether our...
    16: ...echanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.,Chen CW, Leime...
  19. 8fc4 (5,736 bytes)
    14: ...ar mechanism of overcoming Erm-type resistance by macrolides acting together with hygromycin A. Altogether our...
    16: ...echanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.,Chen CW, Leime...
  20. 4p6f (4,732 bytes)
    14: ...ble probes for interrogating nascent peptide-exit tunnel interaction.

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