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- 1vyq (4,614 bytes)
2: ...arum dUTPase provide a platform for anti-malarial drug design==
24: ...at PfdUTPase may be considered as an antimalarial drug target.
26: dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a... - 1w8k (3,948 bytes)
24: ...part. These results are likely to aid vaccine and drug design.
26: Crystal structure of the malaria vaccine candidate apical membrane antigen 1.,Piza... - 1w81 (3,949 bytes)
24: ...part. These results are likely to aid vaccine and drug design.
26: Crystal structure of the malaria vaccine candidate apical membrane antigen 1.,Piza... - 1sme (4,822 bytes)
24: ...on pathway and are novel targets for antimalarial drug development. We have determined the crystal struc... - 1yvb (4,188 bytes)
24: ...plasmodial proteases, suggesting that they confer malaria-specific functions.
26: ...mechanisms of folding and hemoglobin binding by a malarial protease.,Wang SX, Pandey KC, Somoza JR, Sijwali... - 4b12 (3,339 bytes)
14: ..., the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of c...
16: ...ltransferase, A Promising Target for Antimalarial Drug Discovery.,Yu Z, Brannigan JA, Moss DK, Brzozowsk... - Malarial Dihydrofolate Reductase as Drug Target (10,680 bytes)
2: ...alarial strain, the most common and lethal of the malaria species.<ref>Somsak V, Uthaipibull C, Prommana P,...
5: Mutant, Drug Resistant PfDHFR
8: <scene name='Malarial_Dihydrofolate_Reductase_as_Drug_Target/Quadruple_mutant/2'>quadruple mutant</scen...
9: ...addressed in the research of new PfDHFR targeting drugs.
15: ... track would have made it unsuccessful as an oral drug, especially in comparison to its diaminopyrimidin... - 4irf (3,817 bytes)
2: ==Preliminary structural investigations of a malarial protein secretion system==
13: ...aid structure-based design of novel anti-malarial drugs.
15: ...ng protein folding and secretion for antimalarial drug design.,AhYoung AP, Koehl A, Cascio D, Egea PF Pr... - 7e26 (3,116 bytes)
12: ...MMV007839, which facilitates further antimalarial drug design.
14: ...e transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechan... - 7e27 (3,378 bytes)
13: ...MMV007839, which facilitates further antimalarial drug design.
15: ...e transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechan... - 2gh5 (5,036 bytes)
24: ...ivity per se and to contribute to the reversal of drug resistance. The development of menadione chemistr... - 1a5c (4,078 bytes)
23: .... PfALDO is potentially a target for antimalarial drug design as the intraerythrocytic merozoite lifesta...
25: ...fructose-1,6-bisphosphate aldolase from the human malaria parasite Plasmodium falciparum.,Kim H, Certa U, D... - 1onn (4,253 bytes)
23: ...finity inhibitor of IspC. Very recently, its anti-malaria activity in man has been demonstrated in clinical...
25: ...ions for the catalytic mechanism and anti-malaria drug development.,Steinbacher S, Kaiser J, Eisenreich ... - 1ono (4,425 bytes)
24: ...finity inhibitor of IspC. Very recently, its anti-malaria activity in man has been demonstrated in clinical...
26: ...ions for the catalytic mechanism and anti-malaria drug development.,Steinbacher S, Kaiser J, Eisenreich ... - 1onp (4,534 bytes)
24: ...finity inhibitor of IspC. Very recently, its anti-malaria activity in man has been demonstrated in clinical...
26: ...ions for the catalytic mechanism and anti-malaria drug development.,Steinbacher S, Kaiser J, Eisenreich ... - 1u3l (4,740 bytes)
24: ..., these enzymes have been recognised as promising drug targets. We report the crystal structure of Esche... - 1u40 (4,737 bytes)
24: ..., these enzymes have been recognised as promising drug targets. We report the crystal structure of Esche... - 1v8b (4,885 bytes)
24: ...evelop selective PfSAHH inhibitors as therapeutic drugs, only the mammalian SAHH structures are currentl...
26: ...-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum.,Tanaka N, Nakanis... - 1z7d (5,239 bytes)
23: ...of the world. Advances in vaccine development and drug discovery are urgently needed to control these di... - 2a94 (4,280 bytes)
24: ...e, a potential antimalarial drug target. Ideally, drugs directed against this target would be effective ...
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