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- 2o2k (5,833 bytes)
2: ...ture of the Activation Domain of Human Methionine Synthase Isoform/Mutant D963E/K1071N==
10: ...in MS activity could be associated with mild hyperhomocysteinemia, a risk factor for cardiovascular disease and ...
12: ...ne. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
25: ...raction is enhanced in the presence of S-adenosyl-methionine. Binding of the D963E/K1071N mutant activation do...
27: ...tion of the activation domain of human methionine synthase.,Wolthers KR, Toogood HS, Jowitt TA, Marshall KR,... - 1k7y (4,371 bytes)
11: ...ne. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
24: ...omocysteine, methyltetrahydrofolate and S-adenosylmethionine (AdoMet). Here we describe the 3.0 A structure of...
26: ...n alternation switches B(12)-dependent methionine synthase to the activation conformation.,Bandarian V, Patt...
33: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1k98 (4,373 bytes)
11: ...ne. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
24: ...omocysteine, methyltetrahydrofolate and S-adenosylmethionine (AdoMet). Here we describe the 3.0 A structure of...
26: ...n alternation switches B(12)-dependent methionine synthase to the activation conformation.,Bandarian V, Patt...
33: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1msk (2,749 bytes)
2: ==METHIONINE SYNTHASE (ACTIVATION DOMAIN)==
7: ...ACT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
11: ...ne. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
24: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1t7l (5,028 bytes)
2: ...tal Structure of Cobalamin-Independent Methionine Synthase from T. maritima==
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
24: ...)Zn site in the related enzymes, MetH and betaine-homocysteine methyltransferase, by its position in the barrel ...
26: Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved...
33: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1u1h (4,830 bytes)
2: ==A. thaliana cobalamine independent methionine synthase==
7: ...NE'>MET</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+...
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation.<ref>PMID:15024005</ref>
24: ...hydrofolate (CH3-H2PteGlun) to the sulfur atom of homocysteine (Hcy). We report here the first crystal structure...
26: ...e synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.,Ferrer JL, Ravanel S, Robert M, Dumas R J Biol C... - 1u1j (4,908 bytes)
2: ==A. thaliana cobalamine independent methionine synthase==
7: ...NE'>MET</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+...
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation.<ref>PMID:15024005</ref>
24: ...hydrofolate (CH3-H2PteGlun) to the sulfur atom of homocysteine (Hcy). We report here the first crystal structure...
26: ...e synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.,Ferrer JL, Ravanel S, Robert M, Dumas R J Biol C... - 1u1u (4,778 bytes)
2: ==A. thaliana cobalamine independent methionine synthase==
7: ..." id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+...
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation.<ref>PMID:15024005</ref>
24: ...hydrofolate (CH3-H2PteGlun) to the sulfur atom of homocysteine (Hcy). We report here the first crystal structure...
26: ...e synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.,Ferrer JL, Ravanel S, Robert M, Dumas R J Biol C... - 1u22 (4,922 bytes)
2: ==A. thaliana cobalamine independent methionine synthase==
7: ...ID'>HCS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+...
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation.<ref>PMID:15024005</ref>
24: ...hydrofolate (CH3-H2PteGlun) to the sulfur atom of homocysteine (Hcy). We report here the first crystal structure...
26: ...e synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.,Ferrer JL, Ravanel S, Robert M, Dumas R J Biol C... - 1xdj (2,879 bytes)
2: ...ndent Methionine Synthase complexed with Zn2+ and Homocysteine==
7: ...OL'>MRY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+...
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
24: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1xpg (5,258 bytes)
2: ...ndent Methionine Synthase complexed with Zn2+ and Methyltetrahydrofolate==
7: ...OL'>MRY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+...
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
24: ...)Zn site in the related enzymes, MetH and betaine-homocysteine methyltransferase, by its position in the barrel ...
26: Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved... - 1xr2 (5,152 bytes)
2: ...in-Independent Methionine Synthase complexed with Methyltetrahydrofolate==
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
24: ...)Zn site in the related enzymes, MetH and betaine-homocysteine methyltransferase, by its position in the barrel ...
26: Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved...
33: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1q7m (4,246 bytes)
2: ==Cobalamin-dependent methionine synthase (MetH) from Thermotoga maritima (Oxidized, Monocl...
23: ...n to the folate (Fol) domain for remethylation by methyltetrahydrofolate (CH(3)-H(4)folate). Here, we describe crystal str...
25: ...rge domain motions during catalysis by methionine synthase.,Evans JC, Huddler DP, Hilgers MT, Romanchuk G, M...
32: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1q7q (4,241 bytes)
2: ==Cobalamin-dependent methionine synthase (1-566) from T. maritima (Oxidized, Orthorhombic)...
23: ...n to the folate (Fol) domain for remethylation by methyltetrahydrofolate (CH(3)-H(4)folate). Here, we describe crystal str...
25: ...rge domain motions during catalysis by methionine synthase.,Evans JC, Huddler DP, Hilgers MT, Romanchuk G, M...
32: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1q85 (4,469 bytes)
2: ==Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima (Cd2+ complex, S...
7: ...ION'>CD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
24: ...n to the folate (Fol) domain for remethylation by methyltetrahydrofolate (CH(3)-H(4)folate). Here, we describe crystal str...
26: ...rge domain motions during catalysis by methionine synthase.,Evans JC, Huddler DP, Hilgers MT, Romanchuk G, M...
33: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 1q8a (4,550 bytes)
2: ==Cobalamin-dependent methionine synthase (1-566) from Thermotoga maritima (Cd2+:L-Hcy comp...
7: ...ID'>HCS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
24: ...n to the folate (Fol) domain for remethylation by methyltetrahydrofolate (CH(3)-H(4)folate). Here, we describe crystal str...
26: ...rge domain motions during catalysis by methionine synthase.,Evans JC, Huddler DP, Hilgers MT, Romanchuk G, M...
33: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 3bq5 (2,801 bytes)
2: ...ndent Methionine Synthase complexed with Zn2+ and Homocysteine (Monoclinic)==
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
24: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 3bq6 (4,547 bytes)
2: ...e of T. maritima Cobalamin-Independent Methionine Synthase complexed with Zn2+ (Monoclinic)==
11: ...thyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity).
24: ...hyltetrahydrofolate to homocysteine (Hcy) to form methionine, they display markedly different catalytic strate...
26: ...inked to activation of homocysteine in methionine synthases.,Koutmos M, Pejchal R, Bomer TM, Matthews RG, Sm...
33: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 3bul (4,490 bytes)
10: ...ne. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
23: ...ysteine, methyltetrahydrofolate, and S-adenosyl-l-methionine (AdoMet). These same rearrangements appear to pre...
25: A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine liga...
32: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]] - 3iv9 (4,607 bytes)
2: ==Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half in a "His-On" conformation=...
10: ...ne. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
23: ...(s-s)MetH(CT) with cob(II)alamin and S-adenosyl-L-homocysteine represents the enzyme in the reactivation step pr...
25: ...he reactivation of cobalamin-dependent methionine synthase.,Koutmos M, Datta S, Pattridge KA, Smith JL, Matt...
32: *[[Methionine synthase 3D structures|Methionine synthase 3D structures]]
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