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- OspA L03 Group2 (11,042 bytes)
1: =OspA: The Lead to a Cure for Lyme Disease=
18: ... disease. One of the main outer surface proteins, OspA, plays a major role in the ability of the immune ...
23: =='''About OspA'''==
25: ...tem complement system]. Once the complement found OspA on borrelia, it induced an innate response of [ht...
28: ==== Pathology of OspA ==== - Category:Ospa (35 bytes)
1: List of pages with the keyword Ospa - User:Marvin O'Neal/OspA (20,364 bytes)
1: ...ing secondary structures." scene="Studio:G2SecL03/Ospa_default/5"/>
3: ...edia.org/wiki/Neuroborreliosis neuroborreliosis]. OspA has also been used as a vector in working towards...
15: ...> inside the tick. High levels of both OspA and TROSPA are found prior to feeding, but are downregulated...
18: ...4</ref><ref name="rupprecht">PMID: 18097481</ref> OspA is the protein most related to acute Lyme neurobo...
23: <h2>OspA's Role in Invasion</h2> - User:Marvin O'Neal/Antibody OspA and OspB (10,093 bytes)
4: ...abs to their corresponding outer surface protein (OspA and OspB) of ''B. burgdoferi'' leads to the lysis...
8: ...LA-2 is an IgM mAb that targets the C-terminal of OspA.<ref>PMID:107164</ref>
53: ==OspA and LA-2==
56: </td></tr><tr><td bgcolor='#eeeeee'><center>'''OspA-LA2 Complex''' (<scene name='Studio:G1SecL01/2/1'...
57: <scene name='Studio:G1SecL01/2/1'>OspA-LA2 Complex</scene>''':''' <scene name='Studio:G1... - OspA (4,804 bytes)
1: ...tion load='1fj1' size='350' side='right' caption='OspA (magenta and cyan) complex with antibody light ch...
2: == Outer surface protein A (OspA) of the Lyme disease spirochete bacterium ==
5: <scene name='User:Ji_Youn_Park/1fj1_4_24-4/1'>OspA</scene> (Outer surface protein A) is an abundant ...
11: ...r studies need to be done in order to improve the OspA based vaccines.
17: ...nal transducer (Crystal Structure 2012). Although OspA normally has a lipidated N-terminal cysteine to p... - Image:G2L03-OspA-mechanism.jpg (81 bytes)
2: Mechanism of OspA Inflammatory Response - Image:Antibody ospa.png (0 bytes)
- Image:Ospa.gif (52 bytes)
1: This is a picture of OspA in cartoon representation.
Page text matches
- 2z80 (4,864 bytes)
11: ....burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. - 1ggq (3,834 bytes)
24: ... helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spir... - 8tvd (1,538 bytes)
2: ==Fab 221-11 in complex with OspA==
10: [https://www.uniprot.org/uniprot/OSPA_BORBU OSPA_BORBU] - 8tvj (1,537 bytes)
2: ==Fab 227-1 in complex with OspA==
10: [https://www.uniprot.org/uniprot/OSPA_BORBU OSPA_BORBU] - G09SecL04Tpc2 (14,557 bytes)
1: ...1' size='400' frame='true' align='right' caption='OspA Dimer (magenta and cyan) with LA-2 Antibody DImer...
2: ...liminated through antibiotics. On the other hand, OspA has many important functions that are associated ...
5: == OspA's Role in Lyme Disease ==
8: Besides OspA, there are other outer surface proteins or [http:...
10: == Outer Surface Protein A (OspA) == - G14secL04Tpc3 (12,005 bytes)
11: ...33. doi:10.1371/journal.ppat.0030033 http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal...
17: ...spC is upregulated <ref name="transmit" />. Since OspA and OspB are critical for the adherence of the ...
44: [http://www.proteopedia.org/wiki/index.php/OspA OspA] - 1fyw (3,276 bytes)
11: ....burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. - 1fyx (4,874 bytes)
11: ....burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. - 1o77 (4,451 bytes)
10: ....burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. - OspA L03 Group2 (11,042 bytes)
1: =OspA: The Lead to a Cure for Lyme Disease=
18: ... disease. One of the main outer surface proteins, OspA, plays a major role in the ability of the immune ...
23: =='''About OspA'''==
25: ...tem complement system]. Once the complement found OspA on borrelia, it induced an innate response of [ht...
28: ==== Pathology of OspA ==== - Image:1OSP.png (25 bytes)
1: OspA with highlighted SLB - 2z7x (4,126 bytes)
11: ....burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. - 1fj1 (4,496 bytes)
2: ==LYME DISEASE ANTIGEN OSPA IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB LA-2==
23: ...e results provide a rationale for improvements in OspA-based vaccines and suggest possible designs for m...
25: ...protective B-cell epitope in Lyme disease antigen OspA.,Ding W, Huang X, Yang X, Dunn JJ, Luft BJ, Koide... - 1osp (3,949 bytes)
23: ...mportant factor in the worldwide effectiveness of OspA-based vaccines. - 1rjl (4,242 bytes)
23: ...is topologically analogous to the LA-2 epitope of OspA and is centered around OspB Lys-253, a residue es... - G12SecL02Tpc3 (2,844 bytes)
4: In conjunction with OspA, OspB allows B. burgdorferi to adhere to the midg... - 1p4p (4,043 bytes)
23: ...is topologically analogous to the LA-2 epitope of OspA and is centered around OspB Lys-253, a residue es... - 2af5 (4,361 bytes)
2: ==2.5A X-ray Structure of Engineered OspA protein==
10: [https://www.uniprot.org/uniprot/OSPA_BORBU OSPA_BORBU]
23: ...strategy by using Borrelia outer surface protein (OspA) whose single-layer beta-sheet located between tw... - G04SecL04Tpc1 (8,068 bytes)
3: ...ce Protein B (Osp B) and outer surface protein A (OspA) are very important lipoproteins in Lyme Disease ...
21: === Comparison between OspB-H6831 and OspA-LA2===
23: ...'OspA and LA2 bound complex' scene='G04SecL04Tpc1/Ospa/1' />
26: ...tein A <scene name='G04SecL04Tpc1/Ospa_complex/1'>OspA</scene>. It is composed of 21 anti-parallel beta-...
27: ...so, researchers found that buried surface area of OspA in LA-2 Fab is larger than OspB in the H6831Fab<r... - 2fkg (2,320 bytes)
2: ==The Crystal Structure of Engineered OspA==
10: [https://www.uniprot.org/uniprot/OSPA_BORBU OSPA_BORBU]
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