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- Human Prion Protein Dimer (9,254 bytes)
1: ...='450' side='right' caption='Human prion protein (PDB code [[1qlx]])' scene=''>
2: == Prions as a disease causing agent==
4: [[Image:1i4m.png|left|150px|thumb|Human Prion Protein in dimer form [[1i4m]]]]
7: ...s sponge like brain tissue result from pockets of prion aggregation <ref>[http://phil.cdc.gov/PHIL_Images...
9: ...revention: Prions. http://www.cdc.gov/ncidod/dvrd/prions/</ref> and is called PrP<sup>C</sup>.<ref name="... - Category:Prion protein (44 bytes)
1: List of pages with the keyword Prion protein - Category:Prion (36 bytes)
1: List of pages with the keyword Prion - Category:Anti-prion antibody (50 bytes)
1: List of pages with the keyword Anti-prion antibody - Category:Human prion protein (50 bytes)
1: List of pages with the keyword Human prion protein - Category:Prion peptide (44 bytes)
1: List of pages with the keyword Prion peptide - Category:Synthetic prion peptide (54 bytes)
1: List of pages with the keyword Synthetic prion peptide - Prion protein (6,626 bytes)
1: ...of human prion protein precursor globular domain (PDB code [[1hjm]])'>
4: The [[prion protein]] (PrP) is a cell surface glycoprotein, w...
6: ==Prion diseases==
7: The naturally ocuring prion diseases include [http://en.wikipedia.org/wiki/Cr...
8: ...he sporadic, genetic and infectious etiologies of prion diseases can be explained by a simple protein-bas... - Category:Mouse prion protein (50 bytes)
1: List of pages with the keyword Mouse prion protein - Group:SMART:A Physical Model of the Structure of GNNQQNY from Yeast Prion Sup35 (5,995 bytes)
8: ...right' caption='GNNQQNY - a section of the [PSI+] prion' scene='User:David_Stack/Workbench/Movie_companio...
16: ...f GNNQQNY suggests a potential model of how human prions assemble, which could potentially help in develo...
23: ...='Community SMART Team Model - GNNQQNY from Yeast Prion Sup35' scene='User:David_Stack/Workbench/1yjp_our...
26: ...coordinates for this structure as reported in the pdb file 1yjp, from the Howard Hughes Medical Institu...
28: ...cene> The <scene name='User:David_Stack/Workbench/Prion_step_five/1'> oxygen molecules </scene> were colo... - Category:Prion regulatory domain (54 bytes)
1: List of pages with the keyword Prion regulatory domain - Category:Prion-binding protein (52 bytes)
1: List of pages with the keyword Prion-binding protein - Category:Prion- binding protein (53 bytes)
1: List of pages with the keyword Prion- binding protein - Category:Human prion mutant (49 bytes)
1: List of pages with the keyword Human prion mutant - Prion (5,222 bytes)
1: ...ein complex with Cd+ (pink) and Cl- (green) ions (PDB code [[3haf]])'>
8: ...from merging with non-compatible colonies. Yeast prion proteins are Sup35 and Ure2. For more details se...
9: *[[Prion protein]]<br />
10: *[[Human Prion Protein Dimer]]<br />
12: ...ical Model of the Structure of GNNQQNY from Yeast Prion Sup35]]<br /> - Category:C-term mouse prion protein (57 bytes)
1: List of pages with the keyword C-term mouse prion protein - Image:Prion.pdb (0 bytes)
- Category:Prion-like protein (49 bytes)
1: List of pages with the keyword Prion-like protein - Category:Prion-like fold (46 bytes)
1: List of pages with the keyword Prion-like fold - User:Nitzan Dubovski/Prion (11,665 bytes)
1: ==Prion Protein==
2: ...40' side='right' caption='NMR structure of normal Prion protein, residues 121-228' scene=''>
3: ...t causes progressive neurodegenerative disorders. Prion diseases, or transmissible spongiform encephalopa...
4: .... In contrast to all known infectious agents, the prion doesn't contain any nucleic acid.
6: ==The Discovery of Prions==
Page text matches
- 4hse (4,587 bytes)
7: ...bligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hse ProSAT]</span></td></tr>
14: ...04 leading to so called prion curing, the loss of prion-related phenotypes. Here, we present mechanistic ...
16: ...r mechanism of Hsp100 chaperone inhibition by the prion curing agent guanidinium chloride.,Zeymer C, Werb...
20: <div class="pdbe-citations 4hse" style="background-color:#fffaf0;... - 1uw3 (6,370 bytes)
2: ...crystal structure of the globular domain of sheep prion protein==
7: ...ligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uw3 ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uw3 ConSurf].
26: ...rminal globular domain of the ARQ allele of sheep prion protein (PrP). The asymmetric unit contains a sin... - 3zhc (4,478 bytes)
7: ...bligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zhc ProSAT]</span></td></tr>
14: ...ed critical intermediate in the misfolding of the prion protein), a result that explains the observed kin...
20: <div class="pdbe-citations 3zhc" style="background-color:#fffaf0;... - Teaching Scenes, Tutorials, and Educators' Pages (12,171 bytes)
91: *[[Prion protein]]
144: ...e [[:Category:RCSB_PDB_Molecule_of_the_Month|RCSB PDB Molecule of the Month]].
155: <td>[http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_06 Vaults]</td>
160: <td>[http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_05 Influenza Neuraminidase]</td>
165: <td>[http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_04 Oct and Sox Transcription Factors]</t... - 1aml (9,530 bytes)
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aml ProSAT]</span></td></tr>
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aml ConSurf].
25: ...cephalopathy. The sequence of the helical part of prion proteins was observed to be remarkably similar to...
31: <div class="pdbe-citations 1aml" style="background-color:#fffaf0;... - 1e1g (9,341 bytes)
2: ==Human prion protein variant M166V==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1g ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e1g ConSurf].
25: ...ld-type bovine, human, murine, and Syrian hamster prion proteins, but with the present study two localize... - 1e1j (9,339 bytes)
2: ==Human prion protein variant M166V==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1j ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e1j ConSurf].
25: ...ld-type bovine, human, murine, and Syrian hamster prion proteins, but with the present study two localize... - 1e1p (7,391 bytes)
2: ==Human prion protein variant S170N==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1p ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e1p ConSurf].
25: *[[Prion 3D structures|Prion 3D structures]] - 1e1s (9,339 bytes)
2: ==Human prion protein variant S170N==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1s ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e1s ConSurf].
25: ...ld-type bovine, human, murine, and Syrian hamster prion proteins, but with the present study two localize... - 1e1u (4,156 bytes)
2: ==Human prion protein variant R220K==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1u ProSAT]</span></td></tr>
17: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e1u ConSurf].
21: ...ld-type bovine, human, murine, and Syrian hamster prion proteins, but with the present study two localize...
23: ...res of three single-residue variants of the human prion protein.,Calzolai L, Lysek DA, Guntert P, von Sch... - 1e1w (4,154 bytes)
2: ==Human prion protein variant R220K==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e1w ProSAT]</span></td></tr>
17: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e1w ConSurf].
21: ...ld-type bovine, human, murine, and Syrian hamster prion proteins, but with the present study two localize...
23: ...res of three single-residue variants of the human prion protein.,Calzolai L, Lysek DA, Guntert P, von Sch... - 1fkc (3,856 bytes)
2: ==HUMAN PRION PROTEIN (MUTANT E200K) FRAGMENT 90-231==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fkc ProSAT]</span></td></tr>
17: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fkc ConSurf].
21: ...rP(Sc) conversion in the E200K form of hereditary prion disease.
23: ...ons for the mechanism of pathogenesis in familial prion diseases.,Zhang Y, Swietnicki W, Zagorski MG, Sur... - 1fo7 (9,041 bytes)
2: ==HUMAN PRION PROTEIN MUTANT E200K FRAGMENT 90-231==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fo7 ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fo7 ConSurf].
25: ...rP(Sc) conversion in the E200K form of hereditary prion disease. - 1h0l (8,794 bytes)
2: ==HUMAN PRION PROTEIN 121-230 M166C/E221C==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0l ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0l ConSurf].
25: ...r domain with residues 121-230 of a variant human prion protein with two disulfide bonds, hPrP(M166C/E221... - 1hjm (9,173 bytes)
2: ==HUMAN PRION PROTEIN AT PH 7.0==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hjm ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hjm ConSurf].
25: ...NMR structure of the globular domain of the human prion protein (hPrP) with residues 121-230 at pH 7.0 sh... - 1hjn (7,280 bytes)
2: ==HUMAN PRION PROTEIN AT PH 7.0==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hjn ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
21: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hjn ConSurf].
25: *[[Prion|Prion]] - 1i4m (7,719 bytes)
2: ==Crystal structure of the human prion protein reveals a mechanism for oligomerization==
7: ...dbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i4m ProSAT]</span></td></tr>
11: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i4m ConSurf]. - 1jvq (6,558 bytes)
7: ...EOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
8: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jvq ProSAT]</span></td></tr>
22: ...://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jvq ConSurf].
26: ... dementias, including Alzheimer's disease and the prion encephalopathies, arise from the aberrant aggrega...
32: <div class="pdbe-citations 1jvq" style="background-color:#fffaf0;... - 1oeh (7,990 bytes)
2: ==Human prion protein 61-68==
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oeh ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
15: ... PrP aggregation. The knowledge that the cellular prion protein is immobilized on the cell surface along ...
17: The octapeptide repeats in mammalian prion protein constitute a pH-dependent folding and agg... - 1oei (8,318 bytes)
2: ==Human prion protein 61-84==
5: ....doi.org/10.2210/rcsb_pdb/mom_2008_5 10.2210/rcsb_pdb/mom_2008_5]. Full experimental information is ava...
7: ...Bsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oei ProSAT]</span></td></tr>
10: ...iad of microscopic features that characterize the prion diseases consists of (1) spongiform degeneration ...
15: ... PrP aggregation. The knowledge that the cellular prion protein is immobilized on the cell surface along ...
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