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Article title matches
- Category:Sirt (35 bytes)
1: List of pages with the keyword Sirt
Page text matches
- 4i5i (15,193 bytes)
2: ==Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analo...
11: ... SirtT1 75 kDa fragment: catalytically inactive 75SirT1 may be involved in regulation of apoptosis. May ...
14: ...mation sterically prevents substrate binding. The SIRT1/NAD(+)/35 crystal structure defines a novel mech...
16: The 2.5 A crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine d... - Histone deacetylase (2,330 bytes)
1: ...on load='' size='350' side='right' caption='Human sirtuin-3 complex with peptide containing acetylated l...
7: ...d '''sirtuin''' - (Silent Information Regulator) (SIRT) are NAD-dependent HDAC. This protein is bifuncti...
17: ... used in cancer therapy<ref>PMID:11902574</ref>. Sirtuins play a role in cancer, metabolic activity and...
20: ...ded conformation</scene> between the 2 domains of SIRT3 - a large Rossman fold, NAD-binding domain and a... - Category:Sirt (35 bytes)
1: List of pages with the keyword Sirt - 5y2f (5,180 bytes)
2: ==Human SIRT6 in complex with allosteric activator MDL-801==
14: ...cally and pathologically investigate the roles of SIRT6 deacetylation.
16: Identification of a cellularly active SIRT6 allosteric activator.,Huang Z, Zhao J, Deng W, C... - 5y4h (3,549 bytes)
2: ==Human SIRT3 in complex with halistanol sulfate==
14: ... clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.
16: Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine spon... - 6b0u (3,326 bytes)
14: ...cetylation of HupB by Eis. We also found that the SirT-family NAD(+)-dependent deacetylase Rv1151c from ... - Human MnSOD and Cancer Research (9,142 bytes)
19: ...ated in regard to the activation and knockdown of SIRT3. From this, they were able to determine a way to... - 6ljk (4,911 bytes)
2: ==Crystal structure of human Sirt5 in complex with an internally quenched fluoresce...
14: ...ing new substrates and inhibitors targeting human SIRTs.
16: Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.,Yang LL, Wang H... - 6ljm (4,851 bytes)
2: ==Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide sub...
14: ...ing new substrates and inhibitors targeting human SIRTs.
16: Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.,Yang LL, Wang H... - 6ljn (4,850 bytes)
2: ==Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide sub...
14: ...ing new substrates and inhibitors targeting human SIRTs.
16: Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.,Yang LL, Wang H... - 7vke (6,458 bytes)
14: ...atography; SEM: standard error of the mean; SIRT: sirtuins; SPR: surface plasmon resonance; microg: micr... - 9s1z (4,751 bytes)
2: ==Crystal structure of human SIRT2 in complex with the covalent adduct of SirReal-t...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s20 (4,569 bytes)
2: ==Crystal structure of human SIRT2 in complex with SirReal-triazole inhibitor SH10=...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s21 (4,499 bytes)
2: ==Crystal structure of human SIRT2 in complex with SirReal-triazole inhibitor LG023...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s22 (4,665 bytes)
2: ==Crystal structure of human SIRT2 in complex with the covalent adduct of SirReal-t...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s23 (4,426 bytes)
2: ==Crystal structure of human SIRT2 in complex with peptide triazole inhibitor OTDi1...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s24 (4,630 bytes)
2: ==Crystal structure of human SIRT2 in complex with the covalent adduct of peptide t...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s25 (4,371 bytes)
2: ==Crystal structure of human SIRT2 in complex with peptide triazole inhibitor LTDi1...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s26 (4,613 bytes)
2: ==Crystal structure of human SIRT2 in complex with the covalent adduct of peptide t...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord... - 9s27 (4,588 bytes)
2: ==Crystal structure of human SIRT3 in complex with the covalent adduct of peptide t...
14: ...t engagement confirmed by NanoBRET assays. Beyond SIRTs, this inhibition strategy may extend to other NA...
16: ...ad: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors.,Friedrich F, Meleshin M, Papenkord...
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