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1. 1opl (8,297 bytes)
   2: ...l basis for the auto-inhibition of c-Abl tyrosine kinase==
   5: ... Molecule of the Month] feature on ''Src Tyrosine Kinase'' by David S. Goodsell is [https://dx.doi.org/10...
   13: ...of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskelet...
   26: ... the catalytic activity of Abl, but not that of c-Src.
   28: ...al basis for the autoinhibition of c-Abl tyrosine kinase.,Nagar B, Hantschel O, Young MA, Scheffzek K, Vea...
2. 2g1t (8,305 bytes)
   2: ...rc-like Inactive Conformation in the Abl Tyrosine Kinase Domain==
   13: ...of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskelet...
   26: ...formations is a characteristic feature of the Abl kinase domain.
   28: ...rc-like inactive conformation in the abl tyrosine kinase domain.,Levinson NM, Kuchment O, Shen K, Young MA...
   35: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
3. 2g2f (8,336 bytes)
   2: ...rc-like Inactive Conformation in the Abl Tyrosine Kinase Domain==
   13: ...of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskelet...
   26: ...formations is a characteristic feature of the Abl kinase domain.
   28: ...rc-like inactive conformation in the abl tyrosine kinase domain.,Levinson NM, Kuchment O, Shen K, Young MA...
   35: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
4. 2g2h (8,278 bytes)
   2: ...rc-like Inactive Conformation in the Abl Tyrosine Kinase Domain==
   13: ...of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskelet...
   26: ...formations is a characteristic feature of the Abl kinase domain.
   28: ...rc-like inactive conformation in the abl tyrosine kinase domain.,Levinson NM, Kuchment O, Shen K, Young MA...
   35: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
5. 2g2i (8,206 bytes)
   2: ...rc-like Inactive Conformation in the Abl Tyrosine Kinase Domain==
   13: ...of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskelet...
   26: ...formations is a characteristic feature of the Abl kinase domain.
   28: ...rc-like inactive conformation in the abl tyrosine kinase domain.,Levinson NM, Kuchment O, Shen K, Young MA...
   35: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
6. 1iep (7,187 bytes)
   2: ==CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.==
   11: ... NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EG...
   24: ...or inactive), whereas STI-571 requires a specific inactive conformation of Abl.
   26: ...x with the small molecule inhibitors PD173955 and imatinib (STI-571).,Nagar B, Bornmann WG, Pellicena P, Sch...
   33: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
7. 1opk (6,666 bytes)
   2: ...l basis for the auto-inhibition of c-Abl tyrosine kinase==
   11: ... NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EG...
   24: ... the catalytic activity of Abl, but not that of c-Src.
   26: ...al basis for the autoinhibition of c-Abl tyrosine kinase.,Nagar B, Hantschel O, Young MA, Scheffzek K, Vea...
   33: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
8. 2f4j (8,815 bytes)
   2: ...b-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680==
   13: ...of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskelet...
   26: ... The avoidance of the innermost cavity of the Abl kinase domain by VX-680 and the specific recognition of ...
   28: ...b-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.,Young MA, Shah NP, Chao LH, See...
   35: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
9. 2oiq (6,055 bytes)
   2: ...Src kinase domain in complex with the cancer drug imatinib.==
   11: ...lustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates...
   24: ...nce between different inactive states is a key to imatinib binding.
   26: c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermody...
   33: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
10. SandboxPKA (24,333 bytes)
    3: ...ctor-independent cell growth. It also affects the Src/Pax/Fak/Rac pathway. This affects the cytoskeleto...
    4: ...l molecule inhibitors of BCR-Abl that bind to the kinase domain can be used to treat CML <ref>PMID:1215402...
    11: ...have been well studied. Like others, the abelson kinase incorporates a highly conserved bi-lobed structur...
    13: ...d by an SH3 domain, an SH2 domain, and a tyrosine kinase domain. The C-terminal half of c-Abl includes bin...
    17: ... group in the N-terminal domain of c-Abl tyrosine kinase' scene='SandboxPKA/Abl1/4'>
11. 3el7 (6,069 bytes)
    2: ==Crystal structure of c-Src in complex with pyrazolopyrimidine 3==
    11: ...lustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates...
    24: ...on the differential selectivity of Imatinib for c-Src and Abl.
    26: Small molecule recognition of c-Src via the Imatinib-binding conformation.,Dar AC, Lopez MS, Shokat KM...
    33: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
12. 3el8 (6,065 bytes)
    2: ==Crystal structure of c-Src in complex with pyrazolopyrimidine 5==
    11: ...lustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates...
    24: ...on the differential selectivity of Imatinib for c-Src and Abl.
    26: Small molecule recognition of c-Src via the Imatinib-binding conformation.,Dar AC, Lopez MS, Shokat KM...
    33: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
13. 3g6g (6,561 bytes)
    2: ...-Src and Abl by compounds that recognize inactive kinase conformations==
    11: ...lustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates...
    24: ...mpounds block the growth of Ba/F3 cells harboring imatinib-resistant BCR-ABL mutants, including the Thr315Il...
    26: ...-Src and Abl by compounds that recognize inactive kinase conformations.,Seeliger MA, Ranjitkar P, Kasap C,...
    33: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
14. 3g6h (6,458 bytes)
    2: ==Src Thr338Ile inhibited in the DFG-Asp-Out conformati...
    11: ...lustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates...
    24: ...mpounds block the growth of Ba/F3 cells harboring imatinib-resistant BCR-ABL mutants, including the Thr315Il...
    26: ...-Src and Abl by compounds that recognize inactive kinase conformations.,Seeliger MA, Ranjitkar P, Kasap C,...
    33: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
15. Nilotinib (3,614 bytes)
    6: * Drug Class: Receptor Tyrosine Kinase (Especially, PDGFR, KIT & BCR-Abl) Inhibitor
    8: * Expected Sales in Combination with [[Imatinib]]: $5 Billion
    9: ...tion BCR-Abl inhibitor designed to work against [[Imatinib]] resistant CML. Recent studies have revealed tha...
    13: ...69, stabilizing the inhibited conformation of the kinase.<ref>doi:10.1107/S0907444906047287</ref><ref>PMID...
    22: {{:Tyrosine Kinase Inhibitor Pharmacokinetics}}
16. Bcr-Abl and Imatinib (STI571 or Gleevec) (24,270 bytes)
    1: ... group in the N-terminal domain of c-Abl tyrosine kinase (PDB code [[1opk]])' scene='SandboxPKA/Abl1/4'>
    2: ...ctor-independent cell growth. It also affects the Src/Pax/Fak/Rac pathway. This affects the cytoskeleto...
    3: ...l molecule inhibitors of BCR-Abl that bind to the kinase domain can be used to treat CML <ref>PMID:1215402...
    5: See also [[Imatinib]]
    10: ...have been well studied. Like others, the abelson kinase incorporates a highly conserved bi-lobed structur...
17. 2xyn (5,531 bytes)
    2: ==HUMAN ABL2 IN COMPLEX WITH AURORA KINASE INHIBITOR VX-680==
    11: ...des during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskelet...
    14: ... of the DFG motif intermediate between active and inactive conformations, that may also serve as a template ...
    16: ...ctures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of t...
    23: *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
18. Dasatinib (4,026 bytes)
    6: * Drug Class: Receptor Tyrosine Kinase (Especially, PDGFR, KIT & BCR-Abl) Inhibitor
    9: ...f BCR-Abl. Is used to treat patients with certain Imatinib resistant forms of [[Cancer|CML]]. Controversial ...
    13: ...two states, an active state and an auto-regulated inactive state.
    14: ...86, stabilizing the inhibited conformation of the kinase.<ref>doi:10.1107/S0907444906047287</ref><ref>PMID...
    22: {{:Tyrosine Kinase Inhibitor Pharmacokinetics}}
19. Imatinib (4,613 bytes)
    1: ...side='right' scene='Imatinib/Imatinib/2' caption='Imatinib, also known as Gleevec ([[2hyy]])' pspeed='8'>
    6: * Drug Class: Receptor Tyrosine Kinase (Especially PDGFR, BCR-Abl & KIT) Inhibitor
    9: ...s of drugs. It is very specific receptor tyrosine kinase (RTK) inhibitor, binding to Abl, PDGFR and KIT wi...
    10: * See also [[Bcr-Abl and Imatinib (STI571 or Gleevec)]]
    14: ...and stabilizing the inhibited conformation of the kinase.<ref>doi:10.1107/S0907444906047287</ref>
20. Tyrosine kinase (4,743 bytes)
    1: ...8/483859/Cv/1' caption='Human Fyn tyrosine kinase kinase domain with phosphotyrosine in stick model comple...
    5: .../ref>. TKs are classified as [[Receptor tyrosine kinases|receptor-TK]] which are membrane-attached and cy...
    6: For '''Abelson tyrosine kinase''' see:<br />
    7: *[[Bcr-Abl and Imatinib (STI571 or Gleevec)]]<br />
    8: *[[Imatinib]] (Gleevec)<br />

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