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- Category:Thrombin-active-site inhibitor-exo-site inhibitor (80 bytes)
1: List of pages with the keyword Thrombin-active-site inhibitor-exo-site inhibitor
Page text matches
- 1dan (5,989 bytes)
13: ...or VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue f...
26: ...which then activates factors IX and X, leading to thrombin generation and clot formation. We have determined... - 2cno (5,404 bytes)
34: *[[Thrombin 3D Structures|Thrombin 3D Structures]] - 2cn0 (7,541 bytes)
2: ==Complex of Recombinant Human Thrombin with a Designed Inhibitor==
11: ...rombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis...
13: ...://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Thrombin, which cleaves bonds after Arg and Lys, converts ...
26: ...to map the fluorophilicity/fluorophobicity of the thrombin active site, a series of 11 new ligands featuring...
28: ... synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups int... - 1wcc (6,954 bytes)
24: ...ated against five proteins (p38 MAP kinase, CDK2, thrombin, ribonuclease A, and PTP1B). The fragments identi... - 1awf (7,921 bytes)
2: ==NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT==
11: ...rombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis...
13: ...://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Thrombin, which cleaves bonds after Arg and Lys, converts ...
26: ...t. Struct.Biol. 4, 456-462], suggesting the alpha-thrombin/GR133487 complex may be a good model for this rea...
28: ...oduct 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.,Weir... - 1awh (7,597 bytes)
2: ==NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT==
11: ...rombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis...
13: ...://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Thrombin, which cleaves bonds after Arg and Lys, converts ...
26: ...t. Struct.Biol. 4, 456-462], suggesting the alpha-thrombin/GR133487 complex may be a good model for this rea...
28: ...oduct 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.,Weir... - 1avg (4,980 bytes)
2: ==THROMBIN INHIBITOR FROM TRIATOMA PALLIDIPENNIS==
10: ...://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts ...
23: ...bin. These data demonstrate that triabin inhibits thrombin via a novel and unique mechanism that might be of...
25: Structure of the thrombin complex with triabin, a lipocalin-like exosite-bi...
32: *[[Thrombin 3D Structures|Thrombin 3D Structures]] - Sean Swale/Human Thrombin Inhibitor (6,165 bytes)
2: ...PDB=3utu | SIZE=400| SCENE= |right|CAPTION=Human Thrombin, heavy chain (red), light chain (aqua) complex wi...
4: ...ean_Swale/Human_Thrombin_Inhibitor/Active_site/3'>Thrombin</scene> Inhibitor===
5: ...potency in vitro is <scene name='Sean_Swale/Human_Thrombin_Inhibitor/Inhibitor_65/1'>inhibitor 65</scene>.<r...
10: ...break down fibrin clots. The inhibitor bound with Thrombin at rates 26,000x greater than with plasmin,<ref> ...
12: ...the other side. The <scene name='Sean_Swale/Human_Thrombin_Inhibitor/P2_proline/1'>proline</scene> residue i... - 1tbz (7,587 bytes)
2: ==HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N-[5-(AM...
11: ...rombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis...
13: ...://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Thrombin, which cleaves bonds after Arg and Lys, converts ...
26: ...ng site is consistent with previous structures of thrombin complexes with hirulog-3, CVS-995, and hirutonin-...
28: Crystal structures of thrombin with thiazole-containing inhibitors: probes of th... - 2uw3 (6,249 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a... - 2uw0 (6,163 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a... - 2uwp (4,936 bytes)
13: ...pendent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospho...
26: ...to new classes of dual fXa/thrombin and selective thrombin inhibitors with significant oral bioavailability ...
28: ...ctive and dual action orally active inhibitors of thrombin and factor Xa.,Young RJ, Brown D, Burns-Kurtis CL... - 2uwl (4,856 bytes)
2: ...ctive and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa==
13: ...pendent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospho...
26: ...to new classes of dual fXa/thrombin and selective thrombin inhibitors with significant oral bioavailability ...
28: ...ctive and dual action orally active inhibitors of thrombin and factor Xa.,Young RJ, Brown D, Burns-Kurtis CL... - 2uw5 (6,318 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a... - 2uw4 (6,286 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a... - 2uwo (4,866 bytes)
2: ...ctive and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa==
13: ...pendent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospho...
26: ...to new classes of dual fXa/thrombin and selective thrombin inhibitors with significant oral bioavailability ...
28: ...ctive and dual action orally active inhibitors of thrombin and factor Xa.,Young RJ, Brown D, Burns-Kurtis CL... - 2uw7 (6,309 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a... - 4iac (5,991 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a... - 2uzw (7,305 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a... - 2uzt (7,322 bytes)
11: ...ntial for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 a...
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