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- 3bgp (6,606 bytes)
9: ..."><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/w...
10: ...tein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info...
14: ... protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphoryla...
27: ...aditional or aromatic CH..O hydrogen bonds to the kinase hinge. Four diverse actives, of 96 molecules assa...
29: ... four novel inhibitors of the protooncogene Pim-1 kinase.,Pierce AC, Jacobs M, Stuver-Moody C J Med Chem. ... - Student Project 6 for UMass Chemistry 423 Spring 2015 (11,745 bytes)
1: =='''Human Pim-1 Kinase in Complex with an Aminooxadiazole-indole Inhibit...
10: ...uilt mostly upon nonspecific serine and threonine kinases <ref>PMID:19749799</ref>.
12: ...ptosis by phosphorylating the apoptosis signaling kinase 1 (ASK1) which induces apoptosis, therefore incre...
14: ...tudies, it is theorized that inhibiting the Pim-1 kinase could have value as a therapeutic drug to reduce ...
16: ...th ATP. This allows for selectivity for the Pim-1 kinase . - 6p5s (7,185 bytes)
2: ==HIPK2 kinase domain bound to CX-4945==
9: ...tein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/...
13: ...catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the protea...
16: ...arily related dual-specificity tyrosine regulated kinases (DYRKs). Most significant structural differences...
18: The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-i... - 6kzi (5,684 bytes)
2: ==Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives==
8: ..."><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/w...
9: ...tein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info...
13: ... protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphoryla...
16: ... 220- and 8-fold selectivity over Pim-2 and Pim-3 kinases, respectively. - 6l13 (5,441 bytes)
2: ==Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives==
8: ..."><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/ww...
9: ...tein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/...
13: ... protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphoryla...
16: ... 220- and 8-fold selectivity over Pim-2 and Pim-3 kinases, respectively.
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