Function
Spermidine/spermine N-acetyltransferase (SSAT) or Spermidine N-acetyltransferase or diamine acetyltransferase catalyzes the acetylation of spermidine and spermine. SSAT regulates cellular polyamine homeostasis by degrading polyamines via their acetylation. SSAT activity is regulated by polyamine concentration and various toxins, hormones and natural products[1].
Relevance
Several types of cancer are accompanied by increased level of cellular polyamine and compounds which affect SSAT activity are explored as possible anti-cancer drugs[2].
Structural highlights
The . In [3] (colored in cyan). Water molecules are shown as red spheres.