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Statin Pharmacokinetics
From Proteopedia
| Statin Pharmacokinetics at 10mg Dosage | ||||||
|---|---|---|---|---|---|---|
| Parameter | Atorvastatin (Lipitor) | Fluvastatin (Lescol) | Lovastatin (Mevacor) | Simvastatin (Zocor) | Rosuvastatin (Crestor) | Cerivastatin (Baycol) |
| Tmax (hr) | 2.5 | 1 | 3 | 1.5 | 4 | 1.5 |
| Cmax (ng/ml) | 27-66 | 448 | 10-20 | 7.3 | 4.34 | 3.43 |
| Bioavailability (%) | 12 | 19-29 | 5 | 5 | 20 | 60 |
| Protein Binding (%) | 80-90 | 99 | 95 | 95 | 88 | 99 |
| T1/2 (hr) | 15-30 | 2 | 3 | 2.7 | 19 | 2.2 |
| AUC (ng/ml/hr) | 104 | ~150 | 33 | 125 | 48 | 14.5 |
| IC50 (nM) | 154 | 198 | 800 | 66 | 320 | 50-90 |
| Equivalent LDL Reduction Dosage (mg) | 10 | -- | 80 | 20 | 5 | -- |
| Metabolism | Hepatic (CYP3A4) | Hepatic (CYP2C9) | Hepatic (CYP3A4) | Hepatic (CYP3A4) | None | Hepatic (CYP2C8) |
For References, See References
