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Talk:Methylenetetrahydrofolate reductase

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Textbook chapter on folate reactions: Chapter 17.5

Textbook on ping pong mechanisms: Libretext again

1ZP3, 1ZP4, 1ZPT, and 1ZRQ are the E. coli structures with substrate or product bound.

The paper is behind a paywall, but here is the link to the abstract: [1]

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition[1]

Biochemistry of the enzyme: https://www.researchgate.net/profile/Elizabeth-Trimmer/publication/232764343_Methylenetetrahydrofolate_Reductase_Biochemical_Characterization_and_Medical_Significance/links/5541077d0cf232222731506c/Methylenetetrahydrofolate-Reductase-Biochemical-Characterization-and-Medical-Significance.pdf

Your Heading Here (maybe something like 'Structure')

Escherichia coli reca protein-bound DNA (PDB entry 3rec)

Drag the structure with the mouse to rotate


5 methyl folate as dietary supplement: [2]

Making the supplement: [3]

[2]

[3]

  1. ↑ Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW. Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition. Nat Commun. 2018 Jun 11;9(1):2261. doi: 10.1038/s41467-018-04735-2. PMID:29891918 doi:http://dx.doi.org/10.1038/s41467-018-04735-2
  2. ↑ Gilbody S, Lewis S, Lightfoot T. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol. 2007 Jan 1;165(1):1-13. doi: 10.1093/aje/kwj347. Epub 2006 Oct, 30. PMID:17074966 doi:http://dx.doi.org/10.1093/aje/kwj347
  3. ↑ Levin BL, Varga E. MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature. J Genet Couns. 2016 Oct;25(5):901-11. doi: 10.1007/s10897-016-9956-7. Epub 2016, Apr 30. PMID:27130656 doi:http://dx.doi.org/10.1007/s10897-016-9956-7

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