Sofosbuvir. It is metabolized to the active antiviral agent (2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-triphosphate). GS-461203 serves as a defective substrate for the NS5B protein, which is the viral RNA polymerase, thus acts as an inhibitor of viral RNA synthesis.
Telaprevir inhibits the hepatitis C viral enzyme NS3/4A serine protease.
References
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