6FIN, also called DDR1 (Discodein Domain Receptor 1), is a receptor of the collagen.
Function
6 FIN is part of the RTKs family (Receptor Tyrosyne Kinases) which play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.
6FIN is a transferase, so it is an Enzym which catalyses the transfer reaction of a functional group from a donor molecule to an acceptor one. The DDR1 attaches to the collagen and binds to the cellular tissues, so the collagen can bind to the cell.
Disease
The binding of the collagen thanks to DDR1 (fibrosis) impacts several organs: it disrupts normal organs architectur and leads to organ function loss.
Relevance
DDR1 is the subject for the development of novel antifibrotic medications. The inhibition of this protein prevents the diseases progression because it prohibits the link between the collagen and the cell. The inhibition of the DDR1 can stop or reduces the uncontrolled process characterised by the progressive accumulation of extra cellular matrix(ECM), mainly collagen.
Structural highlights
The DDR1 is a protein of 78.1kDa.
Primary Structure
The DDR1 contains 321 amino-acids.
Secundary Structure
6 FIN is formed of 6 principle α-helix.
TertiaryStructure
This protein can bind to 7 ions iodure and a molecule 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.
Multicopper Oxidase CueO 4e9s is a protein containing one chain with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | ![Figure 1: 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.](/wiki/images/thumb/1/15/Imgsrv.png/180px-Imgsrv.png) Figure 1: 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one. [1] |
| ligands: | I iodure |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
![Figure 1: 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.](/wiki/index.php/Image:Imgsrv.png)
