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VCA0042/plzD complexed with c-di-GMP

Introduction

The PDB code 2RDE represents a PilZ protein complexed with cyclic diguanylate monophosphate (c-di-GMP) in Vibrio cholera there is a molecular interaction involved in the regulation of bacterial biofilm formation and motility. The complex is formed by the binding of the small signaling molecule c-di-GMP to a protein domain known as PilZ. This interaction plays a crucial role in bacterial physiology and is implicated in various cellular processes. [1]

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References

  1. Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF. The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J. 2007 Dec 12;26(24):5153-66. doi: 10.1038/sj.emboj.7601918. Epub 2007 Nov 22. PMID: 18034161; PMCID: PMC2140105.
  2. Pecina, Anna, et al. The Stand-Alone PilZ-Domain Protein MotL Specifically Regulates the Activity of the Secondary Lateral Flagellar System in Shewanella putrefaciens. Frontiers in Microbiology, vol. 12, 2021. Frontiers, https://www.frontiersin.org/articles/10.3389/fmicb.2021.668892.
  3. Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF. The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J. 2007 Dec 12;26(24):5153-66. doi: 10.1038/sj.emboj.7601918. Epub 2007 Nov 22. PMID: 18034161; PMCID: PMC2140105.
  4. Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF. The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J. 2007 Dec 12;26(24):5153-66. doi: 10.1038/sj.emboj.7601918. Epub 2007 Nov 22. PMID: 18034161; PMCID: PMC2140105.
  5. Hengge, R. Principles of c-di-GMP signalling in bacteria. Nat Rev Microbiol 7, 263–273 (2009). https://doi.org/10.1038/nrmicro2109
  6. Purificação, Aline Dias da, et al. The World of Cyclic Dinucleotides in Bacterial Behavior. Molecules, vol. 25, n. 10, Janeiro de 2020, p. 2462. www.mdpi.com, https://doi.org/10.3390/molecules25102462.
  7. Purificação, Aline Dias da, et al. The World of Cyclic Dinucleotides in Bacterial Behavior. Molecules, vol. 25, n. 10, Janeiro de 2020, p. 2462. www.mdpi.com, https://doi.org/10.3390/molecules25102462.
  8. Benach J, Swaminathan SS, Tamayo R, Handelman SK, Folta-Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF. The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J. 2007 Dec 12;26(24):5153-66. doi: 10.1038/sj.emboj.7601918. Epub 2007 Nov 22. PMID: 18034161; PMCID: PMC2140105.

[1] [2]

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Eduardo Soares

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