User:George Church

From Proteopedia

Professor of Genetics, Harvard Medical School, Director of the Center for Computational Genetics. 1974-1997 X-ray crystallographic refinement software CORELS and application to tRNA with Sung-Hou Kim and Joel Sussman. 1984 Harvard PhD included the first direct genomic sequencing method, molecular multiplexing tags, which lead to automation & software used at Genome Therapeutics Corp. for the first commercial genome sequence -- pathogen, Helicobacter in 1994. This multiplex solid-phase sequencing evolved into polonies (1999), ABI-SOLiD (2005) & open-source Polonator.org (2007). Innovations in homologous recombination and array-based DNA reading & writing lead to current research and new ethics/safety strategies in Personal Genomics (PGP, 23andme, Knome) & synthetic biology (Codon Devices, SynBERC, LS9).