We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
User:Gisselle Medina/Sandbox7 Leader
From Proteopedia
Introduction
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV). It is the first protein to be translated and cleaves itself from the nascent viral polyprotein chain.It is known to block different cellular functions by different mechanisms. One of the most characterized cellular targets of Lpro is the cellular protein eukaryotic initiation factor 4G (eIF4G). During infection Lpro cleaves the translation factor eIF4G blocking the synthesis of cellular proteins. This provides a mechanism that favors viral translation.
Structure
FMDV Lpro is composed of two secondary structures: and .
| |||||||||||
