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Cystathionine gamma-lyase (Homo sapiens)

Homo sapiens cystathionine gamma-lyase (PDB code 2nmp). Each monomer is in a different color.

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References

  1. 1.0 1.1 Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R. H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem. 2009 Apr 24;284(17):11601-12. doi: 10.1074/jbc.M808026200. Epub 2009, Mar 4. PMID:19261609 doi:10.1074/jbc.M808026200
  2. Messerschmidt A, Worbs M, Steegborn C, Wahl MC, Huber R, Laber B, Clausen T. Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison. Biol Chem. 2003 Mar;384(3):373-86. PMID:12715888
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Sun Q, Collins R, Huang S, Holmberg-Schiavone L, Anand GS, Tan CH, van-den-Berg S, Deng LW, Moore PK, Karlberg T, Sivaraman J. Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S. J Biol Chem. 2009 Jan 30;284(5):3076-85. Epub 2008 Nov 19. PMID:19019829 doi:http://dx.doi.org/10.1074/jbc.M805459200
  4. 4.0 4.1 Adaikan PG, Karim SM. Effects of PGA and PGB compounds on gastrointestinal tract smooth muscle from man and laboratory animals. Prostaglandins. 1976 Jan;11(1):15-22. PMID:1257494 doi:10.1016/0090-6980(76)90168-4
  5. Scott CR, Dassell SW, Clark SH, Chiang-Teng C, Swedberg KR. Cystathioninemia: a benign genetic condition. J Pediatr. 1970 Apr;76(4):571-7. PMID:5420794 doi:10.1016/s0022-3476(70)80407-3
  6. Wang J, Hegele RA. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH). Hum Genet. 2003 Apr;112(4):404-8. Epub 2003 Feb 6. PMID:12574942 doi:10.1007/s00439-003-0906-8

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João Pedro de Carvalho Pereira

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