From Proteopedia

DGAT1: Diglycerol Acyltransferase

Introduction

spinqualitylabelsall models DGAT1 and 6vz1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Structure 1.1 Substrates 1.2 Binding Tunnel 1.3 Catalytic Histidine 2 Disease 2.1 Mutations 3 Relevance 4 Structural highlights Structure Fig 1 This is the reference for our structure [1]. Substrates Binding Tunnel Catalytic Histidine The catalytic residue in DGAT is which is located in the transmembrane region of the L tunnel. Disease disease Mutations Relevance Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

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1. ↑ ^{1.0 1.1} Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 2020 May;581(7808):323-328. doi: 10.1038/s41586-020-2289-6. Epub 2020 May, 13. PMID:32433611 doi:http://dx.doi.org/10.1038/s41586-020-2289-6
2. ↑ ^{2.0 2.1} Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677

Student Contributors

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