User:Mary Ball/Glucagon

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Contents

GLUCAGON


PDB ID 1gcn

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1gcn, resolution 3.00Å ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



About this Structure

1GCN is a Single protein structure of a sequence isolated from the wild boar Sus scrofa. Full crystallographic information is available from OCA, a browser-database for protein structure/function.

For information on the function of gulcagon, see the Glucagon article in Wikipedia at [1].

Refer to the structure and the article to complete the following Quiz.

Quiz

1. Glucagon combines with a receptor inside target cells.

True
False
→ Glucagon combines with a receptor on the surface of target cells.

2. Glucagon is a type of:

Gene
Protein
RNA
Carbohydrate
→Glucagon and insulin are a pair of hormones that control blood glucose levels.

3.

How many amino acids are joined into a chain to form glucagon?

4. What is the biological function of glucagon?

It is an enzyme.
It is a membrane receptor.
It is a hormone.
It is an intracellular hormone receptor.

5. Which of these structures represents glucagon?


Your score is 0 / 0


Abstract for This Structure

X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING

Publication Abstract from PubMed

X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor.

X-ray analysis of glucagon and its relationship to receptor binding., Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T, Nature. 1975 Oct 30;257(5529):751-7. PMID:171582

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Reference

X-ray analysis of glucagon and its relationship to receptor binding., Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T, Nature. 1975 Oct 30;257(5529):751-7. PMID:171582

Page seeded by OCA on Tue Jul 1 05:05:13 2008

Proteopedia Page Contributors and Editors (what is this?)

Mary Ball

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