Overall structure of the Amylin GPCR bound to Amylin ligand

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Introduction

Function

Disease

Alzheimer's

Relevance

Weight Loss

Structural Components

Calcitonin Receptor

RAMP

Peptide

Bypass Motif

The is a series of residues in the midsection of the amylin peptide that are crucial for providing structural specificity for the AMYR. Without RAMP association, the CTR is in a relaxed, fluid state, allowing the binding of calcitonin. When RAMP binds the receptor, it is forced into a new, rigid conformation, which interferes with calcitonin binding. Amylin's bypass motif

Overlay of sCT (orange) and rAmy (green)

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