Structure

Figure 1. The coolest image of this protein EVAH!!!!

Function

B-cell receptor

Disease

Relevance

The human IgM BCR has three domains: extracellular, transmembrane, and intracellular. The antigen binding site (located in the extracellular region) is specific to antigens, but the process is highly conserved across different BCRs. More specifically, the IgM BCR has a unique interaction concerning its Fc chains and a/b subunits. These interactions contribute to the overall structure of the protein. Within the a/b subunits themselves, there are several intermolecular interactions that cause the subunits to remain associated with each other. The following section explores these different domains and interactions in more detail.

Structural highlights