YKL 40

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Structural Highlights

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References

1. Hakala, B. E., White, C. & Recklies, A. D. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J. Biol. Chem. 268, 25803–25810 (1993).

2. Recklies, A. D., White, C. & Ling, H. The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways. Biochem. J. 365, 119–126 (2002).

3. He, C. H. et al. Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor alpha2. Cell Rep. 4, 830–841 (2013).

4. Ngernyuang, N., Yan, W., Schwartz, L. M., Oh, D., Liu, Y. B., Chen, H., & Shao, R. (2018). A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40. Neoplasia (New York, N.Y.), 20(2), 182–192. https://doi.org/10.1016/j.neo.2017.11.011

5. Villar-Piqué, A., Schmitz, M., Hermann, P. et al. Plasma YKL-40 in the spectrum of neurodegenerative dementia. J Neuroinflammation 16, 145 (2019). https://doi.org/10.1186/s12974-019-1531-3

6. Zhao, T., Su, Z., Li, Y. et al. Chitinase-3 like-protein-1 function and its role in diseases. Sig Transduct Target Ther 5, 201 (2020). https://doi.org/10.1038/s41392-020-00303-7

7. Llorens, F., Thüne, K., Tahir, W. et al. YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias. Mol Neurodegeneration 12, 83 (2017). https://doi.org/10.1186/s13024-017-0226-4

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