RNA Interference
From Proteopedia
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(New page: Schematic of RNAi Interference in Mammalian Cells RNA Interference (RNAi) is a system in living cells that helps control the le...) |
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[[Image:500px-ShRNA Lentivirus.png|350px|right|thumb| Schematic of RNAi Interference in Mammalian Cells]] | [[Image:500px-ShRNA Lentivirus.png|350px|right|thumb| Schematic of RNAi Interference in Mammalian Cells]] | ||
| - | [[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand. | + | [[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand. |
Articles in Proteopedia concerning RNA Interference include: | Articles in Proteopedia concerning RNA Interference include: | ||
Revision as of 12:44, 25 September 2010
RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.
Articles in Proteopedia concerning RNA Interference include:
- Flock house virus B2 protein Suppression of RNA Silencing
- Plant Viral Protein p19 Supression of RNA Silencing
- Suppression of RNA Silencing by Viruses
- Tomato aspermy virus protein 2b Suppression of RNA Silencing
To view other Proteopedia pages about diseases & drug targets, See: Pharmaceutical Drug Targets
