RNA Interference
From Proteopedia
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| - | [[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand. | ||
{{Structure | {{Structure | ||
|PDB= 3dlh |SIZE=400|SCENE=RNA_Interference/3dlh/1|CAPTION= guide-strand-containing Argonaute protein silencing complex [[3dlh]], resolution 3.00Å (<scene name='RNA_Interference/3dlh/1'>initial scene</scene>) | |PDB= 3dlh |SIZE=400|SCENE=RNA_Interference/3dlh/1|CAPTION= guide-strand-containing Argonaute protein silencing complex [[3dlh]], resolution 3.00Å (<scene name='RNA_Interference/3dlh/1'>initial scene</scene>) | ||
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dlh OCA], [http://www.ebi.ac.uk/pdbsum/3dlh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3dlh RCSB]</span> | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dlh OCA], [http://www.ebi.ac.uk/pdbsum/3dlh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3dlh RCSB]</span> | ||
}} | }} | ||
| - | + | [[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand. | |
[[Image:500px-ShRNA Lentivirus.png|350px|right|thumb| Schematic of RNAi Interference in Mammalian Cells]] | [[Image:500px-ShRNA Lentivirus.png|350px|right|thumb| Schematic of RNAi Interference in Mammalian Cells]] | ||
{{Structure | {{Structure | ||
| - | |PDB= 1rpu |SIZE=400|SCENE=User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2|CAPTION= viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å (<scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>initial scene</scene>) | + | |PDB= 1rpu |SIZE=400|ALIGN=Left|SCENE=User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2|CAPTION= viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å (<scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>initial scene</scene>) |
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= | ||
Revision as of 19:50, 26 September 2010
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| guide-strand-containing Argonaute protein silencing complex 3dlh, resolution 3.00Å () | |||||||
|---|---|---|---|---|---|---|---|
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.
| |||||||
| viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å () | |||||||
|---|---|---|---|---|---|---|---|
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Articles in Proteopedia concerning RNA Interference include:
- Suppression of RNA Silencing by Viruses
- Plant Viral Protein p19 Supression of RNA Silencing
- Tomato aspermy virus protein 2b Suppression of RNA Silencing
- Flock house virus B2 protein Suppression of RNA Silencing
To view automatically seeded pages concerning RNA Interference See:
To view other Proteopedia pages about diseases & drug targets, See: Pharmaceutical Drug Targets
