This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
User:Lori Wetmore/Sandbox 3
From Proteopedia
(→The Structure of ClC Channels) |
|||
| Line 77: | Line 77: | ||
No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as <i>E. coli</i>. | No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as <i>E. coli</i>. | ||
| - | The basic structure of ClC channels is that of a <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top_double_barrel/2'>"double barrel"</scene>, in which two single-pore monomers combine to form a double-pore channel <ref>PMID:11917096</ref>. | + | ClC channels are composed of four distinct subunits, with each subunit consisting of 18 alpha helices. The basic structure of ClC channels is that of a <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top_double_barrel/2'>"double barrel"</scene>, in which two single-pore monomers combine to form a double-pore channel <ref>PMID:11917096</ref>. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. |
<scene name='User:Lori_Wetmore/Sandbox_3/Orange_top/1'>Orange Top</scene> | <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top/1'>Orange Top</scene> | ||
Revision as of 03:41, 27 September 2010
Contents |
Chloride Channels
Chloride channels come in many varieties.
ClC Channels
The ClC family of chloride channels are present in many species. Mammals contain 9 different types of ClC channels[1]. The members of the CLC channel family can be divided into different groups by a number of different characteristics including intracellular localization, tissue [specificity?], and basic function [2].
| ClC Channels within Homo sapiens | |||
|---|---|---|---|
| Channel Name | Tissue | Location Within Cell | Basic Function |
| ClC-1 | Skeletal Muscle | Plasma Membrane Ion Channel | |
| ClC-2 | Plasma Membrane Ion Channel | ||
| ClC-3 | H+/Cl- Exchange Transporter | ||
| ClC-4 | H+/Cl- Exchange Transporter | ||
| ClC-5 | H+/Cl- Exchange Transporter | ||
| ClC-6 | |||
| ClC-7 | |||
| ClC-Ka | Plasma Membrane Ion Channel | ||
| ClC-Kb | Plasma Membrane Ion Channel | ||
The Structure of ClC Channels
|
No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as E. coli.
ClC channels are composed of four distinct subunits, with each subunit consisting of 18 alpha helices. The basic structure of ClC channels is that of a , in which two single-pore monomers combine to form a double-pore channel [3]. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels.
1ots
2h2p
1kpl
Other Notes and Things
RAINBOW TIME
When viewed in (where the N-terminus is gradually shaded into the C-terminus according to the scale below)
| N | C |
References
- ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001
- ↑ Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. Separate ion pathways in a Cl-/H+ exchanger. J Gen Physiol. 2005 Dec;126(6):563-70. PMID:16316975 doi:10.1085/jgp.200509417
- ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001
