Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {| class="wikitable" border="0px" width="100%" style="text-align:center" |- ! colspan="5" align="center"| DPP4 Inhibitor Pharmacokinetics |- ! Parameter ! Vildagliptin<br/>(Galvus...)
Line 9: Line 9:
|-
|-
! [[Pharmacokinetics#Tmax|T<sub>max</sub>]] (hr)
! [[Pharmacokinetics#Tmax|T<sub>max</sub>]] (hr)
-
! [[Vildagliptin]]<br/>(Galvus)
+
! 1.75
-
! [[Sitagliptin]]<br/>(Januvia)
+
! 1-4
-
! [[Saxagliptin]]<br/>(Onglyza)
+
! 2
|-
|-
! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
Line 19: Line 19:
|-
|-
! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
-
! [[Vildagliptin]]<br/>(Galvus)
+
! 85
-
! [[Sitagliptin]]<br/>(Januvia)
+
! 87
-
! [[Saxagliptin]]<br/>(Onglyza)
+
! [67
|-
|-
! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
-
! [[Vildagliptin]]<br/>(Galvus)
+
! 9
-
! [[Sitagliptin]]<br/>(Januvia)
+
! 38
-
! [[Saxagliptin]]<br/>(Onglyza)
+
! 0
|-
|-
! [[Pharmacokinetics#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
! [[Pharmacokinetics#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
-
! [[Vildagliptin]]<br/>(Galvus)
+
! 2-3
-
! [[Sitagliptin]]<br/>(Januvia)
+
! 12.4
-
! [[Saxagliptin]]<br/>(Onglyza)
+
! 2.5
|-
|-
! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
Line 43: Line 43:
! [[Saxagliptin]]<br/>(Onglyza)
! [[Saxagliptin]]<br/>(Onglyza)
|-
|-
-
! [[Pharmacokinetics#Clearance_.28Cl.29|Clearance]] (L/h)
+
! [[Pharmacokinetics#Clearance_.28Cl.29|Renal Clearance]] (L/h)
-
! [[Vildagliptin]]<br/>(Galvus)
+
! 13.0
-
! [[Sitagliptin]]<br/>(Januvia)
+
! 21.0
-
! [[Saxagliptin]]<br/>(Onglyza)
+
! 13.8
|-
|-
! Dosage (mg)
! Dosage (mg)
-
! [[Vildagliptin]]<br/>(Galvus)
+
! 100
-
! [[Sitagliptin]]<br/>(Januvia)
+
! 100
-
! [[Saxagliptin]]<br/>(Onglyza)
+
! 5
|-
|-
! Metabolism
! Metabolism
Line 58: Line 58:
! [[Saxagliptin]]<br/>(Onglyza)
! [[Saxagliptin]]<br/>(Onglyza)
|}
|}
-
For Pharmacokinetic Data References, see: [[Treatments:AChE Inhibitor References|References]]
+
For Pharmacokinetic Data References, see: [[Treatments:Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics|References]]

Revision as of 17:14, 12 December 2010

DPP4 Inhibitor Pharmacokinetics
Parameter Vildagliptin
(Galvus) 		Sitagliptin
(Januvia) 		Saxagliptin
(Onglyza)
Tmax (hr) 1.75 1-4 2
Cmax (ng/ml) Vildagliptin
(Galvus) 		Sitagliptin
(Januvia) 		Saxagliptin
(Onglyza)
Bioavailability (%) 85 87 [67
Protein Binding (%) 9 38 0
T1/2 (hr) 2-3 12.4 2.5
AUC (ng/ml/hr) Vildagliptin
(Galvus) 		Sitagliptin
(Januvia) 		Saxagliptin
(Onglyza)
IC50 (nM) Vildagliptin
(Galvus) 		Sitagliptin
(Januvia) 		Saxagliptin
(Onglyza)
Renal Clearance (L/h) 13.0 21.0 13.8
Dosage (mg) 100 100 5
Metabolism Vildagliptin
(Galvus) 		Sitagliptin
(Januvia) 		Saxagliptin
(Onglyza)

For Pharmacokinetic Data References, see: References

Proteopedia Page Contributors and Editors (what is this?)

David Canner

Retrieved from "http://52.214.119.220/wiki/index.php/Dipeptidyl_Peptidase-4_Inhibitor_Pharmacokinetics"
Personal tools