Dipeptidyl Peptidase-4 Inhibitor Pharmacokinetics
From Proteopedia
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! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM) | ! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM) | ||
| - | ! | + | ! 3 |
| - | ! | + | ! 18 |
! [[Saxagliptin]]<br/>(Onglyza) | ! [[Saxagliptin]]<br/>(Onglyza) | ||
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Revision as of 17:22, 12 December 2010
| DPP4 Inhibitor Pharmacokinetics | ||||
|---|---|---|---|---|
| Parameter | Vildagliptin (Galvus) | Sitagliptin (Januvia) | Saxagliptin (Onglyza) | |
| Tmax (hr) | 1.75 | 1-4 | 2 | |
| Cmax (ng/ml) | Vildagliptin (Galvus) | Sitagliptin (Januvia) | Saxagliptin (Onglyza) | |
| Bioavailability (%) | 85 | 87 | [67 | |
| Protein Binding (%) | 9 | 38 | 0 | |
| T1/2 (hr) | 2-3 | 12.4 | 2.5 | |
| AUC (ng/ml/hr) | Vildagliptin (Galvus) | Sitagliptin (Januvia) | Saxagliptin (Onglyza) | |
| IC50 (nM) | 3 | 18 | Saxagliptin (Onglyza) | |
| Renal Clearance (L/h) | 13.0 | 21.0 | 13.8 | |
| Dosage (mg) | 100 | 100 | 5 | |
| Metabolism | Vildagliptin (Galvus) | Sitagliptin (Januvia) | Saxagliptin (Onglyza) | |
For Pharmacokinetic Data References, see: References
