3gi2

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Revision as of 08:08, 26 December 2010

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Template:STRUCTURE 3gi2

Contents 1 Human dihydrofolate reductase Q35K mutant inhibitor complex 2 About this Structure 3 See Also 4 Reference

Human dihydrofolate reductase Q35K mutant inhibitor complex

Template:ABSTRACT PUBMED 19719239

About this Structure

3gi2 is a 1 chain structure of Dihydrofolate reductase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Dihydrofolate reductase

Reference

• Gangjee A, Li W, Kisliuk RL, Cody V, Pace J, Piraino J, Makin J. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J Med Chem. 2009 Aug 13;52(15):4892-902. PMID:19719239 doi:10.1021/jm900490a