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Sandbox Reserved 347
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{{STRUCTURE_2iko | PDB=2iko | SCENE=Sandbox_Reserved_347/Close_up/1 }} | {{STRUCTURE_2iko | PDB=2iko | SCENE=Sandbox_Reserved_347/Close_up/1 }} | ||
=Introduction= | =Introduction= | ||
| - | <scene name='Sandbox_Reserved_347/Close_up/1'>Renin</scene> (pronounced /ˈriːnɨn/ REE-nin) is also known as angiotensinogenase, a monospecific enzyme that participates in the body's renin-angiotensin system (RAS). Renin is responsible for catalyzing the rate-limiting step in the synthesis of angiotensin II. Once renin and pro-renin bind to the pro-renin receptor, there is an increased enzymatic activity and additional physiological effects. <ref name= | + | <scene name='Sandbox_Reserved_347/Close_up/1'>Renin</scene> (pronounced /ˈriːnɨn/ REE-nin) is also known as angiotensinogenase, a monospecific enzyme that participates in the body's renin-angiotensin system (RAS). Renin is responsible for catalyzing the rate-limiting step in the synthesis of angiotensin II. Once renin and pro-renin bind to the pro-renin receptor, there is an increased enzymatic activity and additional physiological effects. <ref name="hypertension">doi:10.1016/j.jacc.2007.10.027 |
</ref> | </ref> | ||
==Structure== | ==Structure== | ||
| - | Renin belongs in the family called aspartic proteases because they use an aspartate residue for catalysis of their peptide substrate.<ref name= | + | Renin belongs in the family called aspartic proteases because they use an aspartate residue for catalysis of their peptide substrate.<ref name="hypertension"/> |
==Biochemistry== | ==Biochemistry== | ||
Revision as of 04:05, 4 April 2011
| This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada. |
To get started:
More help: Help:Editing |
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| 2iko, resolution 1.90Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | REN (Homo sapiens) | ||||||||
| Activity: | Renin, with EC number 3.4.23.15 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Introduction
(pronounced /ˈriːnɨn/ REE-nin) is also known as angiotensinogenase, a monospecific enzyme that participates in the body's renin-angiotensin system (RAS). Renin is responsible for catalyzing the rate-limiting step in the synthesis of angiotensin II. Once renin and pro-renin bind to the pro-renin receptor, there is an increased enzymatic activity and additional physiological effects. [1]
Structure
Renin belongs in the family called aspartic proteases because they use an aspartate residue for catalysis of their peptide substrate.[1]
Biochemistry
Renin is an aspartyl protease. [2]
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Function
Renin plays a key role in the Renin-Angiotension sysmtem (RAS). This system is responsible for the control of blood pressure and salt balances in mammals.
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