Fatty acid synthase
From Proteopedia
(New page: <!-- Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. Or use the four-green-boxes-button to insert scrollable text adjacent to a Jmol applet. Che...) |
|||
| Line 1: | Line 1: | ||
| + | {{STRUCTURE_2jfk| PDB=2jfk | SIZE=400| SCENE= |right|CAPTION=Human FAS complex with malonyl-CoA, [[2jfk]] }} | ||
| + | |||
<!-- | <!-- | ||
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | ||
| Line 5: | Line 7: | ||
--> | --> | ||
'''Fatty acid synthase''' (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP). | '''Fatty acid synthase''' (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP). | ||
| + | |||
| + | == 3D structures of fatty acid synthase== | ||
[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br /> | [[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br /> | ||
| Line 47: | Line 51: | ||
[[2vkz]] - yFAS α+β subunits + cerulenin | [[2vkz]] - yFAS α+β subunits + cerulenin | ||
| + | |||
| + | [[Category:Topic Page]] | ||
Revision as of 10:42, 29 February 2012
Fatty acid synthase (FAS) catalizes the synthesis of palmitate from acetyl CoA and malonyl CoA into long chain fatty acid. FAS is a multi-domain enzyme. It contains an acyl carrier protein domain (ACP).
3D structures of fatty acid synthase
1kp9 – MtFAS CmaA1 – Mycobacterium tuberculosis
1xkt – hFAS thioesterase domain – human
2jfd – hFAS MAT domain
3hhd - hFAS KS-MAT domain
2cf2, 2vz8 – pFAS – pig
2uv8, 3hmj – yFAS α+β subunits - yeast
2pff, 2was – yFAS α subunit
2uv9 – TlFAS α subunits – Thermomyces lanuginosus
2uva – TlFAS β subunits
2png – FAS ACP domain – rat
1t8k – EcFAS ACP domain - Escherichia coli
2k92, 2k93, 2k94 - EcFAS ACP domain – NMR
FAS complex with fatty acid
1kpg – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine
1kph – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine
1kpi – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine
3hem - MtFAS CmaA1 + dioctylamine
3tjm – hFAS thioesterase domain + fatty acid
2fae – EcFAS ACP domain + decanethioate
2fad – EcFAS ACP domain + heptanthioate
FAS complex with reactants
2jfk – hFAS + malonyl CoA
2uvc – TlFAS β subunits + NADP
2uvb – TlFAS α subunits + NADP
2wat – yFAS α subunit + CoA
2vzp – pFAS + NADP
FAS complex with protein
2fhs – EcFAS ACP domain + enoyl-ACP reductase
3ejb - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme
3ejb, 3eje - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid
2cg5 - hFAS ACP domain + AASD-PPT
FAS complex with inhibitor
2vkz - yFAS α+β subunits + cerulenin
