Amino acid oxidase
From Proteopedia
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| + | {{STRUCTURE_2jb1| PDB=2jb1 | SIZE=400| SCENE= |right|CAPTION=Viper L-amino acid oxidase complex with L-alanine, [[2jb1]] }} | ||
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[[1ve9]] - pDAO + benzoate<br /> | [[1ve9]] - pDAO + benzoate<br /> | ||
[[1evi]] – pDAO + dihydro-pyrrolium-carboxylate<br /> | [[1evi]] – pDAO + dihydro-pyrrolium-carboxylate<br /> | ||
| - | [[ | + | [[1c0k]] – RtDAO + L-lactate<br /> |
[[1c0p]] – RtDAO + peroxide<br /> | [[1c0p]] – RtDAO + peroxide<br /> | ||
[[1c0i]] - RtDAO + aminobenzoate<br /> | [[1c0i]] - RtDAO + aminobenzoate<br /> | ||
Revision as of 11:14, 15 March 2012
Template:STRUCTURE 2jb1 Amino acid oxidase catalyzes the oxidation of amino acids to the keto acid producing ammonia and hydrogen peroxide. These enzymes oxidize D-amino acids (DAO) and L-amino acids (LAO). The LAO oxidation products are 2-oxo acid, ammonia and hydrogen peroxide. LAO is widely found in snake venom. DAOs oxidize neutral and basic D-amino acids. Some DAOs are used in cancer therapy as inducers of oxidative stress and apoptosis. DAO and LAO use FAD as a cofactor.
3D structures of amino acid oxidase
D-amino acid oxidase
1kif – pDAO – pig
1c0l – RtDAO – Rhodosporidium toruloides
1dao – pDAO + methyl-oxo-valeric acid
1ddo – pDAO + imino-tryptophan
1an9 – pDAO + aminobenzoate
1ve9 - pDAO + benzoate
1evi – pDAO + dihydro-pyrrolium-carboxylate
1c0k – RtDAO + L-lactate
1c0p – RtDAO + peroxide
1c0i - RtDAO + aminobenzoate
L-amino acid oxidase
2jae – RoLAO – Rhodococcus opacus
1f8r – CrLAO + citrate – Calloselasma rhodostoma
1f8s - CrLAO + aminobenzoate
1tdk – HvLAO + L-vinylglycine – Halys viper
1tdn - HvLAO + L-leucine
1tdo - HvLAO + L-phenylalanine
2jb1 - RoLAO + L-alanine
2jb2 - RoLAO + L-phenylalanine
2jb3 - RoLAO + aminobenzoate
3kve – LAO + Zn – Vipera ammodytes
