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Multiple sclerosis

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Interferons alpha and beta interact with a receptor at the surface of <ref>[http://www.jbc.org/content/282/28/20045.full?sid=cbf08059-44d4-4957-8ea7-0351cab9c2ac] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." ''J Biol Chem'' 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200</ref>
Interferons alpha and beta interact with a receptor at the surface of <ref>[http://www.jbc.org/content/282/28/20045.full?sid=cbf08059-44d4-4957-8ea7-0351cab9c2ac] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." ''J Biol Chem'' 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200</ref>
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 +
Interferon receptor
<scene name='Multiple_sclerosis/Ifnr_domains_labeled/1'>Interferon receptor domains</scene>
<scene name='Multiple_sclerosis/Ifnr_domains_labeled/1'>Interferon receptor domains</scene>
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<scene name='Multiple_sclerosis/Ifnr_c_domain_labeled/1'>C-domain, with one disulfide bond</scene>
<scene name='Multiple_sclerosis/Ifnr_c_domain_labeled/1'>C-domain, with one disulfide bond</scene>
<scene name='Multiple_sclerosis/Ifnr_linker_region_labeled/1'>linker region</scene>
<scene name='Multiple_sclerosis/Ifnr_linker_region_labeled/1'>linker region</scene>
- 
<scene name='Multiple_sclerosis/Ifnr_termini_labeled/1'>termini regions, no structure.</scene>
<scene name='Multiple_sclerosis/Ifnr_termini_labeled/1'>termini regions, no structure.</scene>
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<scene name='Multiple_sclerosis/Ifnr_clash_n-c/1'>eight clashes between domains</scene><ref name="Interferon Receptor Structure">PMID:12842042</ref>
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<scene name='Multiple_sclerosis/Ifnr_clash_n-c/1'>eight clashes between domains</scene>
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Interferon receptor bound to interferon alpha
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+
-
<ref name="Interferon Receptor Structure">PMID:12842042</ref>
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<scene name='Multiple_sclerosis/Ifna/1'>Interferon alpha</scene>
__NOTOC__
__NOTOC__
</StructureSection>
</StructureSection>
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=== A comparative representation of the three forms of DNA ===
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''Sources''<ref>http://203.129.231.23/indira/nacc/</ref>
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{|
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|<applet load='IfnA.pdb' name='A' size='400' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Multiple_sclerosis/Ifna/1'/>
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|<applet load='IfnB.pdb' name='B' size='400' frame='true' align='right' caption='Interferon Beta' align='left' scene='Multiple_sclerosis/Interferon_beta/1'/>
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|}
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{{Clear}}
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<center>
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'''Synchronize the applets showing Interferons Alpha and Beta by clicking the checkbox'''
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<jmol>
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<jmolCheckbox>
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<target>A</target>
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<!--<scriptWhenChecked>set syncMouse ON;set syncScript OFF;sync jmolAppletB; sync > "set syncMouse
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ON;set syncScript OFF"</scriptWhenChecked>-->
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<scriptWhenChecked> sync jmolAppletB </scriptWhenChecked>
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<scriptWhenUnchecked> sync OFF</scriptWhenUnchecked>
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<text> Synchronize</text>
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</jmolCheckbox>
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</jmol>
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</center>
== Other Treatments==
== Other Treatments==

Revision as of 04:04, 9 April 2012

Please have patience as I edit this page over the next few weeks! Thank you!--Kirsten Eldredge 04:22, 9 April 2012 (IDT)

Click on the green links to the left to see key structural features of Interferon Beta (PDB entry 1ifa)

Drag the structure with the mouse to rotate


A comparative representation of the three forms of DNA

Sources[6]

Interferon Alpha

Drag the structure with the mouse to rotate

Interferon Beta

Drag the structure with the mouse to rotate

Synchronize the applets showing Interferons Alpha and Beta by clicking the checkbox

Other Treatments

Copaxone

References

  1. ↑ Voet, D., Voet, J.G., and C. Pratt. Fundamentals of Biochemistry 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.
  2. ↑ Kudo M. Management of hepatocellular carcinoma: from prevention to molecular targeted therapy. Oncology. 2010 Jul;78 Suppl 1:1-6. Epub 2010 Jul 8. PMID:20616576 doi:10.1159/000315222
  3. ↑ http://www.uniprot.org/uniprot/P00784
  4. ↑ [1] Samuel, C.E. "Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Inteferon Regulatory Factors." J Biol Chem 2007 282: 20045-20046. First Published on May 14, 2007, doi:10.1074/jbc.R700025200
  5. ↑ Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J. The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. Structure. 2003 Jul;11(7):791-802. PMID:12842042
  6. ↑ http://203.129.231.23/indira/nacc/

Relevant 3D Structures

Interferon Beta

1au1 - Homo sapiens

1ifa, 1wu3 - Mus musculus

Interferon Receptors

3s98, 3se3, 3se4, 1n6u, 1n6v, 2hym, 2kz1, 2lag, 3s8w, 3s9d - Homo sapiens

Proteopedia Page Contributors and Editors (what is this?)

Kirsten Eldredge

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