Interferon
From Proteopedia
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| - | < | + | <StructureSection load='2hym' size='500' side='right' caption='Click on the green links to the left to view the structural aspects of interferons. PDB ID: [[2hym]])' scene='Interferons/Interferonaandreceptor/2'> |
| - | + | ==Interferon-β== | |
| - | + | <scene name='Multiple_sclerosis/Interferon_beta/9'>Interferon-β</scene> is a protein growth factor that stimulates an antiviral defense. Its encoding gene is one of only two known vertebrate structural genes that lacks introns.<ref name="Biochem Text">Voet, D., Voet, J.G., and C. Pratt. ''Fundamentals of Biochemistry'' 3rd Edition. Hoboken, NJ: John Wiley and Sons, 2008. Print.</ref> | |
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| - | --> | + | Interferon-β is a relatively simple biological response modifier, with several <scene name='Multiple_sclerosis/Interferon_beta_labeled/1'>identifiable regions</scene>. It consists of five <scene name='Multiple_sclerosis/Ifnb_helices_in_color/1'>alpha helices</scene>, as well as multiple interconnecting <scene name='Multiple_sclerosis/Interferon_beta_loops/2'>loop regions</scene>. Helices A, B and D run <scene name='Multiple_sclerosis/Ifnb_parallel_abd/3'>parallel to one another</scene>, and helices C and E run <scene name='Multiple_sclerosis/Ifnb_antiparallel/1'>anti-parallel</scene> to the other three helices, but <scene name='Multiple_sclerosis/Ifnb_antiparallel_ce/3'>parallel</scene> to one another. Helix A consists of residues 6-23; Helix B consists of residues 49-65; Helix C consists of residues 77-91; Helix D consists of residues 112-131; and Helix E consists of residues 135-155.<ref name="Structure Ifn B">PMID:20616576</ref><ref name="UniProt">http://www.uniprot.org/uniprot/P00784</ref> |
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| + | ==Interferon-α== | ||
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| + | ==Interferon-γ== | ||
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| + | </StructureSection> | ||
=== A comparative representation of three interferons === | === A comparative representation of three interferons === | ||
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|<applet load='1ITF.pdb' name='A' size='300' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Interferons/Ifn_alpha/4'/> | |<applet load='1ITF.pdb' name='A' size='300' frame='true' align='right' caption='Interferon Alpha' align='left' scene='Interferons/Ifn_alpha/4'/> | ||
|<applet load='1IFA.pdb' name='B' size='300' frame='true' align='right' caption='Interferon Beta' align='left' scene='Interferons/Interferon_beta/3'/> | |<applet load='1IFA.pdb' name='B' size='300' frame='true' align='right' caption='Interferon Beta' align='left' scene='Interferons/Interferon_beta/3'/> | ||
| - | |<applet load='1HIG.pdb' name='Z' size='300' frame='true' align='right' caption='Interferon Gamma' align='left' scene='Interferons/Ifn_gamma/3'/> | + | |<applet load='1HIG.pdb' name='Z' size='300' frame='true' align='right' caption='Interferon Gamma' align='left' scene='Interferons/Ifn_gamma/3'/>| |
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Revision as of 01:05, 22 April 2012
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A comparative representation of three interferons
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Synchronize the three applets showing interferons alpha, beta, and gamma by clicking the checkbox
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Kirsten Eldredge, Alexander Berchansky, Joel L. Sussman, Karl Oberholser, Jaime Prilusky
