Sulfotransferase

From Proteopedia

Revision as of 09:58, 30 April 2012

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Sulfotransferase (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system. The various human STs are named SULT### and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).

3D structures of sulfotransferase

Estrogen ST

1aqy – mST + PAP – mouse
1aqu – mST + estradiol + PAP
1bo6 - mST + VO4 + PAP
1hy3 - hST (mutant) + PAP – human
1g3m - hST + tetrachloro-biphenyl-diol + PAP

Arylsulfate ST

3elq - EcST – Escherichia coli
3ets – EcST + methylumbelliferone
3ett - EcST + p-nitrophenol + sulfate

Hydroxysteroid ST

1efh - hST + PAP

Alcohol ST

1j99 - hST + androsterone derivative
1ov4 - hST (mutant) + androsterone derivative

Pregnenolone ST

1q1q - hST + PAP

Cholesterol ST

1q1z - hST + PAP
1q20, 1q22 - hST + cholesterol derivative + PAP

Heparan sulfate ST

1vkj - mST (mutant) + PAP
1t8t - hST catalytic domain + PAP
3f5f – ST/MBP + PAP - chicken

Heparan sulfate glucosamine 3-o-ST

1zrh - hST + PAP
3bd9 - hST (mutant) + PAP
1t8u - hST catalytic domain + tetrasaccharide + PAP
3uan - mST + pentasaccharide + PAP

Tyrosine-ester ST

2zpt, 2zyt - mST + PAP
2zvp, 2zyv, 2zyw - mST + p-nitrophenol + PAP
2zyu - mST + p-nitrophenyl sulfate + PAP
2zvq - mST + α-naphthol + PAP

Tyrosylprotein ST

3ap1, 3ap2 - hST + peptide + PAP
3ap3 - hST + PAP

SULT1C2

2ad1 – hST 3bfx - hST (mutant) + PAP
2gwh - hST + pentachlorophenol + PAP

SULT4A1

1zd1 – hST

SULT1A3

2a3r – hST + dopamine + PAP
1cjm - hST + sulfate

SULT1A1

3u3j - hST + PAP
2d06 – hST + estradiol + PAP
3qvu, 3u3r – hST (mutant) + p-nitrophenol + PAP
3qvv - hST (mutant) + hydroxyl-chromene-carbonitrile + PAP
1ls6 - hST + p-nitrophenol + PAP
3u3k - hST + 3-naphthol + PAP
3u3m, 3u3o - hST + 3-cyano-7-hydroxycoumarin + PAP

SULT1A2

1z28, 1z29 - hST + hydroxyl-acetylamino fluorine

SULT1B1

2z5f - hST + PAP
3ckl - hST + resveratrol + PAP

SULT2A1

2qp3, 2qp4 - hST (mutant) + aetiocholanolone
3f3y - hST + lithocholic acid + PAP

STF0 ST

1tex, 2zq5 - ST – Mycobacterium smegmatis

3rnl - ST – Alicyclobacillus acidocaldarius