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3dg8
From Proteopedia
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{{STRUCTURE_3dg8| PDB=3dg8 | SCENE= }} | {{STRUCTURE_3dg8| PDB=3dg8 | SCENE= }} | ||
===Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP=== | ===Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP=== | ||
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{{ABSTRACT_PUBMED_19146480}} | {{ABSTRACT_PUBMED_19146480}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3dg8]] is a 4 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DG8 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | ||
| + | *[[Thymidylate synthase|Thymidylate synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019146480</ref><references group="xtra"/> |
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Anderson, K S.]] | [[Category: Anderson, K S.]] | ||
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[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 28 09:48:23 2009'' | ||
Revision as of 00:20, 26 July 2012
Contents |
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
Template:ABSTRACT PUBMED 19146480
About this Structure
3dg8 is a 4 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
See Also
Reference
- Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS. Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. ACS Chem Biol. 2009 Jan 16;4(1):29-40. PMID:19146480 doi:10.1021/cb8002804
