This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3c2i
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
[[Image:3c2i.png|left|200px]] | [[Image:3c2i.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3c2i", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3c2i| PDB=3c2i | SCENE= }} | {{STRUCTURE_3c2i| PDB=3c2i | SCENE= }} | ||
===The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF=== | ===The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_18313390}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18313390 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_18313390}} | {{ABSTRACT_PUBMED_18313390}} | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: Angelman syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Encephalopathy, neonatal severe OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Mental retardation, X-linked, Lubs type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Mental retardation, X-linked, syndromic 13 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Rett syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Rett syndrome, preserved speech variant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]], Autism, susceptibility to, X-linked-3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300005 300005]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3c2i]] is a 3 chain structure of [[Methyl CpG Binding Protein 2]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C2I OCA]. | |
| + | |||
| + | ==See Also== | ||
| + | *[[Methyl CpG Binding Protein 2|Methyl CpG Binding Protein 2]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018313390</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bird, A P.]] | [[Category: Bird, A P.]] | ||
| Line 34: | Line 22: | ||
[[Category: Schmiedeberg, L.]] | [[Category: Schmiedeberg, L.]] | ||
[[Category: Walkinshaw, M D.]] | [[Category: Walkinshaw, M D.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Asx-st-motif]] | [[Category: Asx-st-motif]] | ||
| - | [[Category: Chromosomal rearrangement]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Dna-binding]] | [[Category: Dna-binding]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protein-methylated dna complex]] | [[Category: Protein-methylated dna complex]] | ||
[[Category: Repressor]] | [[Category: Repressor]] | ||
[[Category: Transcription regulator]] | [[Category: Transcription regulator]] | ||
[[Category: Water mediated recognition]] | [[Category: Water mediated recognition]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:31:25 2009'' | ||
Revision as of 15:39, 26 July 2012
Contents |
The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF
Template:ABSTRACT PUBMED 18313390
About this Structure
3c2i is a 3 chain structure of Methyl CpG Binding Protein 2 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD. MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell. 2008 Feb 29;29(4):525-31. PMID:18313390 doi:10.1016/j.molcel.2007.12.028
