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Enolase multiple sequence alignment

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This page is a supplement to Introduction to Evolutionary Conservation. The portion of the multiple sequence alignment (MSA) below with a pink background is enlarged on that page.

Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis.

Key: IDENTICAL(*) SIMILAR(.) different

Consensus Percentage is set to 100%.

1    ENO_DROME| Drosophila melanogaster --------mt IkaIkARqIy DSRGNPTVEv DLtt-elglf rAavPSGAST 41
2              ENOA_HUMAN| Homo sapiens ---------s IlkIhAReIf DSRGNPTVEv DLft-skglf rAavPSGAST 40
3    ENO_METJA| Methanococcus janaschii mlynmderfe IkdIvAReVi DSRGNPTVEv EVitkgngyg sAivPSGAST 50
4           ENO_ECOLI| Escherichia coli --------sk IvkIiGReIi DSRGNPTVEa EVhleggfvg mAaaPSGAST 42
5          ENO_BACSU| Bacillus subtilis -------mpy IvdVyAReVl DSRGNPTVEv EVytetgafg rAlvPSGAST 43
6  4ENL Yeast| Saccharomyces cerevisiae ---------a VskVyARsVy DSRGNPTVEv ELtt-ekgvf rSivPSGAST 40

                                                     . . .* . ********* ..          . ******

1    ENO_DROME| Drosophila melanogaster GvhEALElRD nDKanYhGKS VlkAVghVNd tLgpelIkan ldvvdQasID 91
2              ENOA_HUMAN| Homo sapiens GiyEALElRD nDKtrYmGKG VskAVehINk tIapalVskk lnvteQekID 90
3    ENO_METJA| Methanococcus janaschii GthEALElRD kEK-rFgGKG VlmAVenVNs iIrpeiLg-- ydarmQreID 97
4           ENO_ECOLI| Escherichia coli GsrEALElRD gDKsrFlGKG VtkAVaaVNg pIaqalIg-- kdakdQagID 90
5          ENO_BACSU| Bacillus subtilis GeyEAVElRD gDKdrYlGKG VltAVnnVNe iIapelLg-- fdvteQnaID 91
6  4ENL Yeast| Saccharomyces cerevisiae GvhEALEmRD gDKskWmGKG VlhAVknVNd vIapafVkan idvsdQkaVD 90

                                          * **.* ** .* . **. * ** .*   .   .         * .*

1    ENO_DROME| Drosophila melanogaster nfmIklDGTe NKSKfGANAI LGVSlAvaKA GAakkgvPLY khIAdlagn- 140
2              ENOA_HUMAN| Homo sapiens klmIemDGTe NKSKfGANAI LGVSlAvcKA GAvekgvPLY rhIAdlagn- 139
3    ENO_METJA| Methanococcus janaschii timIelDGTp NKSRlGANAI LAVSlAvaKA AAatakiPLY kyLGgfn--- 144
4           ENO_ECOLI| Escherichia coli kimIdlDGTe NKSKfGANAI LAVSlAnaKA AAaakgmPLY ehIAelngt- 139
5          ENO_BACSU| Bacillus subtilis qllIelDGTe NKGKlGANAI LGVSmAcaRA AAdflqiPLY qyLGgfn--- 138
6  4ENL Yeast| Saccharomyces cerevisiae dflIslDGTa NKSKlGANAI LGVSlAasRA AAaeknvPLY khLAdlsksk 140

                                             * *** **.. ***** *.** * .* .*     ***    .

1    ENO_DROME| Drosophila melanogaster -keiilPVPa fNVINGGsHA gnkLamQEFM IlPtGAtsft EAmKmGSeVY 189
2              ENOA_HUMAN| Homo sapiens -sevilPVPa fNVINGGsHA gnkLamQEFM IlPvGAanfr EAmRiGAeVY 188
3    ENO_METJA| Methanococcus janaschii --syvmPVPm mNVINGGkHA gndLdlQEFM ImPvGAtsis EAvRmGSeVY 192
4           ENO_ECOLI| Escherichia coli pgkysmPVPm mNIINGGeHA dnnVdiQEFM IqPvGAktvk EAiRmGSeVF 189
5          ENO_BACSU| Bacillus subtilis --sktlPVPm mNIVNGGeHA dnnVdiQEFM ImPvGApnfr EAlRmGAqIF 186
6  4ENL Yeast| Saccharomyces cerevisiae tspyvlPVPf lNVLNGGsHA ggaLalQEFM IaPtGAktfa EAlRiGSeVY 190

*** *..*** ** . **** * * ** ** . *. ..

1    ENO_DROME| Drosophila melanogaster HhLknVikaK fgldataVGD EGGfAPnIqs nkEALnlIsd AIakAGyt-- 237
2              ENOA_HUMAN| Homo sapiens HnLknVikeK ygkdatnVGD EGGfAPnIle nkEGLelLkt AIgkAGyt-- 236
3    ENO_METJA| Methanococcus janaschii HvLknVileK ygknavnVGD EGGfAPpLkt srEALdlLte SVkkAGye-- 240
4           ENO_ECOLI| Escherichia coli HhLakVlkaK g--mntaVGD EGGyAPnLgs naEALavIae AVkaAGyelg 237
5          ENO_BACSU| Bacillus subtilis HsLksVlsaK g--lntaVGD EGGfAPnLgs neEALqtIve AIekAGfkpg 234
6  4ENL Yeast| Saccharomyces cerevisiae HnLksLtkkR ygasagnVGD EGGvAPnIqt aeEALdlIvd AIkaAG---- 238

                                          ** .   .        *** *** ** .     *.* .   .. **

1    ENO_DROME| Drosophila melanogaster gkIeiGmDvA ASEFYk--dG qYdLdfknek sdksqwlpad klanlykefi 285
2              ENOA_HUMAN| Homo sapiens dkVviGmDvA ASEFFr--sG kYdLdfksp- ddpsryispd qladlyksfi 283
3    ENO_METJA| Methanococcus janaschii deVvfAlDaA ASEFYk--dG yYyVegkk-- ------ltre elldyykalv 280
4           ENO_ECOLI| Escherichia coli kdItlAmDcA ASEFYk--dG kYvLagegn- ----kaftse efthfleelt 280
5          ENO_BACSU| Bacillus subtilis eeVklAmDaA SSEFYnkedG kYhLsgeg-- ----vvktsa emvdwyeelv 278
6  4ENL Yeast| Saccharomyces cerevisiae gkVkiGlDcA SSEFFk--dG kYdLdfknpn sdkskwltgp qladlyhslm 286

                                            . . * * .***.    * * .

1    ENO_DROME| Drosophila melanogaster kdFPIVSIED pfdqdhWeAw snltgctd-- IQIVGDDLtV TNpkrIatAV 333
2              ENOA_HUMAN| Homo sapiens kdYPVVSIED pfdqddWgAw qkftasag-- IQVVGDDLtV TNpkrIakAV 331
3    ENO_METJA| Methanococcus janaschii deYPIVSIED pfheedFeGf amitkeld-- IQIVGDDLfV TNverLrkGI 328
4           ENO_ECOLI| Escherichia coli kqYPIVSIED gldesdWdGf ayqtkvlgdk IQLVGDDLfV TNtkiLkeGI 330
5          ENO_BACSU| Bacillus subtilis skYPIISIED gldendWeGh kllterlgkk VQLVGDDLfV TNtkkLseGI 328
6  4ENL Yeast| Saccharomyces cerevisiae krYPIVSIED pfaeddWeAw shffktag-- IQIVADDLtV TNpkrIatAI 334

                                            .*..****       . .             .*.*.*** * **   . ..

1    ENO_DROME| Drosophila melanogaster ekkacncLLL KvNQIGtVtE siaAhllAkk nGWgtmVSHR SGETEDsfIG 383
2              ENOA_HUMAN| Homo sapiens nekscncLLL KvNQIGsVtE slqAcklAqa nGWgvmVSHR SGETEDtfIA 381
3    ENO_METJA| Methanococcus janaschii emkaanaLLL KvNQIGtLsE avdAaqlAfr nGYgvvVSHR SGETEDttIA 378
4           ENO_ECOLI| Escherichia coli ekgiansILI KfNQIGsLtE tlaAikmAkd aGYtavISHR SGETEDatIA 380
5          ENO_BACSU| Bacillus subtilis kngvgnsILI KvNQIGtLtE tfdAiemAkr aGYtavISHR SGETEDstIA 378
6  4ENL Yeast| Saccharomyces cerevisiae ekkaadaLLL KvNQIGtLsE sikAaqdSfa aGWgvmVSHR SGETEDtfIA 384

                                                 .*. . **** . *    *   .    *.   .*** ****** *.

1    ENO_DROME| Drosophila melanogaster DLvVGlstGQ IKTGApcRsE RlAKyNQILR IEeeIGagvk FaGksfgkpq 433
2              ENOA_HUMAN| Homo sapiens DLvVGlctGQ IKTGApcRsE RlAKyNQLLR IEeeLGskak FaGrnfrnpl 431
3    ENO_METJA| Methanococcus janaschii DLsVAlnsGQ IKTGApaRgE RtAKyNQLIR IEqeLG-lsk YaGrnfrcpf 427
4           ENO_ECOLI| Escherichia coli DLaVGtaaGQ IKTGSmsRsD RvAKyNQLIR IEeaLGekap YnGrkeikgq 430
5          ENO_BACSU| Bacillus subtilis DIaVAtnaGQ IKTGApsRtD RvAKyNQLLR IEdqLAetaq YhGinsfynl 428
6  4ENL Yeast| Saccharomyces cerevisiae DLvVGlrtGQ IKTGApaRsE RlAKlNQLLR IEeeLGdnav FaGenfhhgd 434

*. *. ** ****. * . * ** **..* ** .. . *

Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%:

33% (142) IDENTICAL(*) 16% (68) SIMILAR(.) 52% (226) different

Definitions of SIMILAR groups of amino acids:

ILV   Ile Leu Val      hydrophobic, aliphatic / medium-sized side-chain
FWY   Phe Trp Tyr      hydrophobic, aromatic / large side-chain (Tyr polar)
KRH   Lys Arg His      + charge
DE    Asp Glu          - charge
GAS   Gly Ala Ser      small
P     Pro              helix breaking
C     Cys              disulfide-forming
TNQM  Thr Asn Gln Met  polar (except Met)

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Enolase multiple sequence alignment

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@@ Line 1: / Line 1: @@
+This page is a supplement to [[Introduction to Evolutionary Conservation]]. The portion of the multiple sequence alignment (MSA) below with <span style="background:pink;">&nbsp;a pink background&nbsp;</span> is enlarged on that page.
+----
 Multiple Sequence Alignment (MSA) for enolase, an enzyme in glycolysis.
-Key:   IDENTICAL(*)   SIMILAR(.)   different
+Key:   '''IDENTICAL'''(*) &nbsp;  SIMILAR(.)  &nbsp; different
 Consensus Percentage is set to 100%.
-<pre>
+----
+<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
+mso-bidi-font-family:"Courier New"'>&nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME|
+Drosophila melanogaster &nbsp;--------mt IkaIkA<b>R</b>qIy <b>DSRGNPTVE</b>v
+DLtt-elglf rAav<b>PSGAST</b> 41<br>
+&nbsp;2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENOA_HUMAN|
+Homo sapiens &nbsp;---------s IlkIhA<b>R</b>eIf <b>DSRGNPTVE</b>v DLft-skglf
+rAav<b>PSGAST</b> 40<br>
+&nbsp;3&nbsp;&nbsp;&nbsp;&nbsp;ENO_METJA| Methanococcus janaschii
+&nbsp;mlynmderfe IkdIvA<b>R</b>eVi <b>DSRGNPTVE</b>v EVitkgngyg sAiv<b>PSGAST</b>
+<br>
+&nbsp;4&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_ECOLI|
+Escherichia coli &nbsp;--------sk IvkIiG<b>R</b>eIi <b>DSRGNPTVE</b>a
+EVhleggfvg mAaa<b>PSGAST</b> 42<br>
+&nbsp;5&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_BACSU|
+Bacillus subtilis &nbsp;-------mpy IvdVyA<b>R</b>eVl <b>DSRGNPTVE</b>v
+EVytetgafg rAlv<b>PSGAST</b> 43<br>
+&nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;---------a VskVyA<b>R</b>sVy
+<b>DSRGNPTVE</b>v ELtt-ekgvf rSiv<b>PSGAST</b> 40</span></p>
+<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
+mso-bidi-font-family:"Courier New"'><span style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><span
+style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span>.<span
+style="mso-spacerun: yes">&nbsp; </span>. .* .<span style="mso-spacerun:
+yes">&nbsp; </span>*********<span style="mso-spacerun: yes">&nbsp;
+</span>..<span style="mso-spacerun: yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+</span>.<span style="mso-spacerun: yes">&nbsp; </span>******<br>
+<br>
 &nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME| Drosophila melanogaster &nbsp;<b>G</b>vh<b>EA</b>L<b>E</b>l<b>RD</b>
 nD<b>K</b>anYh<b>GK</b>S <b>V</b>lk<b>AV</b>ghV<b>N</b>d tLgpelIkan ldvvd<b>Q</b>asI<b>D</b>
@@ Line 22: / Line 54: @@
 &nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;<b>G</b>vh<b>EA</b>L<b>E</b>m<b>RD</b>
 gD<b>K</b>skWm<b>GK</b>G <b>V</b>lh<b>AV</b>knV<b>N</b>d vIapafVkan idvsd<b>Q</b>kaV<b>D</b>
-<o:p></o:p></span></p>
+</span></p>
 <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
@@ Line 53: / Line 85: @@
 &nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;dfl<b>I</b>sl<b>DGT</b>a
 <b>NK</b>SKl<b>GANAI</b> <b>L</b>G<b>VS</b>l<b>A</b>asR<b>A</b> A<b>A</b>aeknv<b>PLY</b>
-khLAdlsksk 140<o:p></o:p></span></p>
+khLAdlsksk 140</span></p>
 <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
@@ Line 81: / Line 113: @@
 &nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;tspyvl<b>PVP</b>f
 l<b>N</b>VL<b>NGG</b>s<b>HA</b> ggaLal<b>QEFM</b> <b>I</b>a<b>P</b>t<b>GA</b>ktfa
-<b>EA</b>lRi<b>G</b>SeVY 190<o:p></o:p></span></p>
+<b>EA</b>lRi<b>G</b>SeVY 190</span></p>
 <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
@@ Line 89: / Line 121: @@
 style="mso-spacerun: yes">&nbsp;&nbsp;&nbsp; </span>.<span style="mso-spacerun:
 yes">&nbsp; </span>**** * * **<span style="mso-spacerun:
-yes">&nbsp;&nbsp;&nbsp;&nbsp; </span>** . *. ..<o:p></o:p></span></p>
+yes">&nbsp;&nbsp;&nbsp;&nbsp; </span>** . *. ..</span></p>
 <span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-font-family:
@@ Line 113: / Line 145: @@
 ne<b>E</b>A<b>L</b>qtIve AIek<b>AG</b>fkpg 234<br>
 &nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;<b>H</b>n<b>L</b>ksLtkkR
-ygasagn<b>VGD</b> <b>EGG</b>v<b>AP</b>nIqt ae<b>E</b>A<b>L</b>dlIvd AIka<b>AG</b>hd&#8212;238<o:p></o:p></span></p>
+ygasagn<b>VGD</b> <b>EGG</b>v<b>AP</b>nIqt ae<b>E</b>A<b>L</b>dlIvd AIka<b>AG</b>---- 238</span></p>
-<p class=MsoNormal><!--[if gte vml 1]><v:rect id="_x0000_s1027" style='position:absolute;
+<p class=MsoNormal><span
- margin-left:243.1pt;margin-top:13.05pt;width:140.25pt;height:90pt;z-index:251657728;
- mso-wrap-edited:f' wrapcoords="-346 -180 -462 360 -462 22860 22293 22860 22408 1260 22177 0 21831 -180 -346 -180"
- filled="f" fillcolor="#3f80cd" strokecolor="red" strokeweight="1.5pt">
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-  focusposition="" focussize=",90" type="gradient">
-  <o:fill v:ext="view" type="gradientUnscaled"/>
- </v:fill>
- <v:shadow on="t" opacity="22938f" css:blur="38100f" offset="0"/>
- <v:textbox inset=",7.2pt,,7.2pt"/>
-</v:rect><![endif]--><![if !vml]><span style='mso-ignore:vglayout;position:
-relative;z-index:251657728'><span style='position:absolute;left:220px;
-top:-33px;width:155px;height:106px'><img width=155 height=106
-src="msa3d_4enl_msa_files/image001.gif" v:shapes="_x0000_s1027"></span></span><![endif]><span
 style='font-size:10.0pt;font-family:"Courier New";mso-bidi-font-family:"Courier New"'><span
 style="mso-spacerun:
 yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 </span><span style="mso-spacerun:
-yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span>*
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span>**<span style="mso-spacerun: yes">&nbsp; </span>.<span style="mso-spacerun:
-*<span style="mso-spacerun: yes">&nbsp; </span>.<span style="mso-spacerun:
 yes">&nbsp;&nbsp; </span>.<span style="mso-spacerun:
 yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>*** *** ** .<span
@@ Line 142: / Line 160: @@
 <span style="mso-spacerun:
 yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
-</span>~~~~~~~~~~~~~~~~~~~~~<br>
+</span>
-&nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME| Drosophila melanogaster &nbsp;gkIeiGm<b>D</b>v<b>A</b>
-A<b>SEF</b>Yk--d<b>G</b> q<b>Y</b>dLdfknek sdksqwlpad klanlykefi 285<br>
+<br>
+&nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME| Drosophila melanogaster <span style="background:pink;">&nbsp;gkIeiGm<b>D</b>v<b>A</b>
+A<b>SEF</b>Yk--d<b>G</b></span> q<b>Y</b>dLdfknek sdksqwlpad klanlykefi 285<br>
 &nbsp;2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENOA_HUMAN|
-Homo sapiens &nbsp;dkVviGm<b>D</b>v<b>A</b> A<b>SEF</b>Fr--s<b>G</b> k<b>Y</b>dLdfksp-
+Homo sapiens <span style="background:pink;">&nbsp;dkVviGm<b>D</b>v<b>A</b> A<b>SEF</b>Fr--s<b>G</b></span> k<b>Y</b>dLdfksp-
 ddpsryispd qladlyksfi 283<br>
-&nbsp;3&nbsp;&nbsp;&nbsp;&nbsp;ENO_METJA| Methanococcus janaschii &nbsp;deVvfAl<b>D</b>a<b>A</b>
+&nbsp;3&nbsp;&nbsp;&nbsp;&nbsp;ENO_METJA| Methanococcus janaschii <span style="background:pink;">&nbsp;deVvfAl<b>D</b>a<b>A</b>
-A<b>SEF</b>Yk--d<b>G</b> y<b>Y</b>yVegkk-- ------ltre elldyykalv 280<br>
+A<b>SEF</b>Yk--d<b>G</b></span> y<b>Y</b>yVegkk-- ------ltre elldyykalv 280<br>
 &nbsp;4&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_ECOLI|
-Escherichia coli &nbsp;kdItlAm<b>D</b>c<b>A</b> A<b>SEF</b>Yk--d<b>G</b> k<b>Y</b>vLagegn-
+Escherichia coli <span style="background:pink;">&nbsp;kdItlAm<b>D</b>c<b>A</b> A<b>SEF</b>Yk--d<b>G</b></span> k<b>Y</b>vLagegn-
-----kaftse efthfleelt 280<br>
+ ----kaftse efthfleelt 280<br>
 &nbsp;5&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_BACSU|
-Bacillus subtilis &nbsp;eeVklAm<b>D</b>a<b>A</b> S<b>SEF</b>Ynked<b>G</b> k<b>Y</b>hLsgeg--
+Bacillus subtilis <span style="background:pink;">&nbsp;eeVklAm<b>D</b>a<b>A</b> S<b>SEF</b>Ynked<b>G</b></span> k<b>Y</b>hLsgeg--
-----vvktsa emvdwyeelv 278<br>
+ ----vvktsa emvdwyeelv 278<br>
-&nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;gkVkiGl<b>D</b>c<b>A</b>
+&nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae <span style="background:pink;">&nbsp;gkVkiGl<b>D</b>c<b>A</b>
-S<b>SEF</b>Fk--d<b>G</b> k<b>Y</b>dLdfknpn sdkskwltgp qladlyhslm 286<o:p></o:p></span></p>
+S<b>SEF</b>Fk--d<b>G</b></span> k<b>Y</b>dLdfknpn sdkskwltgp qladlyhslm 286</span></p>
 <p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
@@ Line 171: / Line 191: @@
 <span style="mso-spacerun:
 yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
-</span>~~~~~~~~~~~~~~~~~~~~~<br>
+</span><br>
 &nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME| Drosophila melanogaster &nbsp;kdF<b>P</b>IV<b>SIED</b>
 pfdqdhWeAw snltgctd-- I<b>Q</b>I<b>V</b>G<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAV
@@ Line 189: / Line 209: @@
 &nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;krY<b>P</b>IV<b>SIED</b>
 pfaeddWeAw shffktag-- I<b>Q</b>I<b>V</b>A<b>DDL</b>t<b>V</b> <b>TN</b>pkrIatAI
-</pre>
+</span></p>
+<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
+mso-bidi-font-family:"Courier New"'><span style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+</span><span style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span>.*..****<span
+style="mso-spacerun: yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>. .<span
+style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+</span>.*.*.*** * **<span style="mso-spacerun: yes">&nbsp;&nbsp; </span>.<span
+style="mso-spacerun: yes">&nbsp; </span>..<br>
+<br>
+&nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME| Drosophila melanogaster
+&nbsp;ekkacncL<b>L</b>L <b>K</b>v<b>NQIG</b>tVt<b>E</b> sia<b>A</b>hllAkk n<b>G</b>WgtmV<b>SHR</b>
+<b>SGETED</b>sf<b>I</b>G 383<br>
+&nbsp;2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENOA_HUMAN|
+Homo sapiens &nbsp;nekscncL<b>L</b>L <b>K</b>v<b>NQIG</b>sVt<b>E</b> slq<b>A</b>cklAqa
+n<b>G</b>WgvmV<b>SHR</b> <b>SGETED</b>tf<b>I</b>A 381<br>
+&nbsp;3&nbsp;&nbsp;&nbsp;&nbsp;ENO_METJA| Methanococcus janaschii
+&nbsp;emkaanaL<b>L</b>L <b>K</b>v<b>NQIG</b>tLs<b>E</b> avd<b>A</b>aqlAfr n<b>G</b>YgvvV<b>SHR</b>
+<b>SGETED</b>tt<b>I</b>A 378<br>
+&nbsp;4&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_ECOLI|
+Escherichia coli &nbsp;ekgiansI<b>L</b>I <b>K</b>f<b>NQIG</b>sLt<b>E</b> tla<b>A</b>ikmAkd
+a<b>G</b>YtavI<b>SHR</b> <b>SGETED</b>at<b>I</b>A 380<br>
+&nbsp;5&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_BACSU|
+Bacillus subtilis &nbsp;kngvgnsI<b>L</b>I <b>K</b>v<b>NQIG</b>tLt<b>E</b> tfd<b>A</b>iemAkr
+a<b>G</b>YtavI<b>SHR</b> <b>SGETED</b>st<b>I</b>A 378<br>
+&nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;ekkaadaL<b>L</b>L
+<b>K</b>v<b>NQIG</b>tLs<b>E</b> sik<b>A</b>aqdSfa a<b>G</b>WgvmV<b>SHR</b> <b>SGETED</b>tf<b>I</b>A
+</span></p>
+<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
+mso-bidi-font-family:"Courier New"'><span style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+</span>.*. . **** . *<span style="mso-spacerun: yes">&nbsp;&nbsp;&nbsp;
+</span>*<span style="mso-spacerun: yes">&nbsp;&nbsp; </span>.<span
+style="mso-spacerun: yes">&nbsp;&nbsp;&nbsp; </span>*.<span
+style="mso-spacerun: yes">&nbsp;&nbsp; </span>.*** ******<span
+style="mso-spacerun: yes">&nbsp; </span>*.<br>
+<br>
+&nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME| Drosophila melanogaster &nbsp;<b>D</b>Lv<b>V</b>Glst<b>GQ</b>
+<b>IKTG</b>Apc<b>R</b>sE <b>R</b>l<b>AK</b>y<b>NQ</b>IL<b>R</b> <b>IE</b>eeIGagvk
+Fa<b>G</b>ksfgkpq 433<br>
+&nbsp;2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENOA_HUMAN|
+Homo sapiens &nbsp;<b>D</b>Lv<b>V</b>Glct<b>GQ</b> <b>IKTG</b>Apc<b>R</b>sE <b>R</b>l<b>AK</b>y<b>NQ</b>LL<b>R</b>
+<b>IE</b>eeLGskak Fa<b>G</b>rnfrnpl 431<br>
+&nbsp;3&nbsp;&nbsp;&nbsp;&nbsp;ENO_METJA| Methanococcus janaschii &nbsp;<b>D</b>Ls<b>V</b>Alns<b>GQ</b>
+<b>IKTG</b>Apa<b>R</b>gE <b>R</b>t<b>AK</b>y<b>NQ</b>LI<b>R</b> <b>IE</b>qeLG-lsk
+Ya<b>G</b>rnfrcpf 427<br>
+&nbsp;4&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_ECOLI|
+Escherichia coli &nbsp;<b>D</b>La<b>V</b>Gtaa<b>GQ</b> <b>IKTG</b>Sms<b>R</b>sD
+<b>R</b>v<b>AK</b>y<b>NQ</b>LI<b>R</b> <b>IE</b>eaLGekap Yn<b>G</b>rkeikgq 430<br>
+&nbsp;5&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_BACSU|
+Bacillus subtilis &nbsp;<b>D</b>Ia<b>V</b>Atna<b>GQ</b> <b>IKTG</b>Aps<b>R</b>tD
+<b>R</b>v<b>AK</b>y<b>NQ</b>LL<b>R</b> <b>IE</b>dqLAetaq Yh<b>G</b>insfynl 428<br>
+&nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;<b>D</b>Lv<b>V</b>Glrt<b>GQ</b>
+<b>IKTG</b>Apa<b>R</b>sE <b>R</b>l<b>AK</b>l<b>NQ</b>LL<b>R</b> <b>IE</b>eeLGdnav
+Fa<b>G</b>enfhhgd 434</span></p>
+<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
+mso-bidi-font-family:"Courier New"'><span style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
+</span>*. *.<span style="mso-spacerun: yes">&nbsp;&nbsp; </span>** ****.<span
+style="mso-spacerun: yes">&nbsp; </span>* . * ** **..* **<span
+style="mso-spacerun: yes">&nbsp; </span>..<span style="mso-spacerun:
+yes">&nbsp;&nbsp;&nbsp;&nbsp; </span>. *</span></p>
+<span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-font-family:
+"Times New Roman";mso-bidi-font-family:"Courier New";mso-ansi-language:EN-US;
+mso-fareast-language:EN-US'><br clear=ALL style='page-break-before:always'>
+</span>
+<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";
+mso-bidi-font-family:"Courier New"'>&nbsp;1&nbsp;&nbsp;&nbsp;&nbsp;ENO_DROME|
+Drosophila melanogaster &nbsp;-- 433<br>
+&nbsp;2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENOA_HUMAN|
+Homo sapiens &nbsp;ak 433<br>
+&nbsp;3&nbsp;&nbsp;&nbsp;&nbsp;ENO_METJA| Methanococcus janaschii &nbsp;-- 427<br>
+&nbsp;4&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_ECOLI|
+Escherichia coli &nbsp;a- 431<br>
+&nbsp;5&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;ENO_BACSU|
+Bacillus subtilis &nbsp;nk 430<br>
+&nbsp;6&nbsp;&nbsp;4ENL Yeast| Saccharomyces cerevisiae &nbsp;kl 436<br>
+</span></p>
+----
 Summary of categories applied to a total of 436 residues in the PDB file sequence for a consensus level setting of 100%:
 % (142) IDENTICAL(*)   16% (68) SIMILAR(.)   52% (226) different
-Definitions of SIMILAR groups of amino acids:
-ILV       Ile Leu Val          hydrophobic, aliphatic / medium-sized side-chain
+Definitions of SIMILAR groups of amino acids:<pre>
-FWY     Phe Trp Tyr         hydrophobic, aromatic / large side-chain (Tyr polar)
+ILV   Ile Leu Val      hydrophobic, aliphatic / medium-sized side-chain
-KRH     Lys Arg His         + charge
+FWY   Phe Trp Tyr      hydrophobic, aromatic / large side-chain (Tyr polar)
-DE        Asp Glu                - charge
+KRH   Lys Arg His      + charge
-GAS     Gly Ala Ser           small
+DE    Asp Glu          - charge
-P           Pro                        helix breaking
+GAS   Gly Ala Ser      small
-C           Cys                       disulfide-forming
+P     Pro              helix breaking
+C     Cys              disulfide-forming
 TNQM  Thr Asn Gln Met  polar (except Met)
+</pre>