Chaperonin
From Proteopedia
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== 3D Structures of Chaperonin == | == 3D Structures of Chaperonin == | ||
| - | ''Updated | + | ''Updated January 2013'' |
===Group I=== | ===Group I=== | ||
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[[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]], [[2yey]] – EcGroEL (mutant) - ''Escherichia coli''<BR /> | [[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]], [[2yey]] – EcGroEL (mutant) - ''Escherichia coli''<BR /> | ||
[[3e76]], [[2nwc]], [[1xck]], [[1ss8]] – EcGroEL<BR /> | [[3e76]], [[2nwc]], [[1xck]], [[1ss8]] – EcGroEL<BR /> | ||
| - | [[3c9v]], [[3cau]] – EcGroEL – Cryo EM<BR /> | + | [[3c9v]], [[3cau]], [[2ynj]] – EcGroEL – Cryo EM<BR /> |
| - | [[2c7e]], [[1gr5]] - EcGroEL (mutant) – Cryo EM<BR /> | + | [[2c7e]], [[1gr5]], [[4aaq]] - EcGroEL (mutant) – Cryo EM<BR /> |
[[1dk7]] - EcGroEL apical domain<br /> | [[1dk7]] - EcGroEL apical domain<br /> | ||
[[1fy9]], [[1fya]], [[1kid]], [[1jon]] – EcGroEL apical domain (mutant) <BR /> | [[1fy9]], [[1fya]], [[1kid]], [[1jon]] – EcGroEL apical domain (mutant) <BR /> | ||
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[[1kp8]] - EcGroEL (mutant) + ATP<BR /> | [[1kp8]] - EcGroEL (mutant) + ATP<BR /> | ||
| + | [[4aar]], [[4aas]], [[4aau]], [[4ab2]], [[4ab3]] - EcGroEL (mutant) + ATP – Cryo EM<br /> | ||
[[1sx3]] - EcGroEL + ATP<BR /> | [[1sx3]] - EcGroEL + ATP<BR /> | ||
[[1sx4]] - EcGroEL + ADP<BR /> | [[1sx4]] - EcGroEL + ADP<BR /> | ||
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[[2xsm]] – bCPN CCT – bovine<BR /> | [[2xsm]] – bCPN CCT – bovine<BR /> | ||
| - | [[3p9d]], [[3p9e]] – CPN CCT - yeast<br /> | + | [[3p9d]], [[3p9e]], [[4d8q]], [[4d8r]] – CPN CCT - yeast<br /> |
[[3iyg]] - bCPN CCT – Cryo EM<BR /> | [[3iyg]] - bCPN CCT – Cryo EM<BR /> | ||
[[3ktt]] - bCPN CCT β subunit – Cryo EM<BR /> | [[3ktt]] - bCPN CCT β subunit – Cryo EM<BR /> | ||
Revision as of 09:09, 29 January 2013
Chaperonins (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see Chaperonins in Wikipedia.
The most characterized CPN are in the GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya.
3D Structures of Chaperonin
Updated January 2013
Group I
Large subunit
3m6c – MtGroEL1 apical domain – Mycobacterium tuberculosis
1sjp, 3rtk – MtGroEL2 residues 42-539
3fbh, 2eu1, 1j4z, 1kpo, 1oel, 1grl, 2yey – EcGroEL (mutant) - Escherichia coli
3e76, 2nwc, 1xck, 1ss8 – EcGroEL
3c9v, 3cau, 2ynj – EcGroEL – Cryo EM
2c7e, 1gr5, 4aaq - EcGroEL (mutant) – Cryo EM
1dk7 - EcGroEL apical domain
1fy9, 1fya, 1kid, 1jon – EcGroEL apical domain (mutant)
1srv – TtCPN60 apical domain - Thermus thermophilus
3osx - CPN60 apical domain – Xenorhabdus nematophila
1iok – CPN60 – Paracoccus denitrificans
Large subunit binary complex
1kp8 - EcGroEL (mutant) + ATP
4aar, 4aas, 4aau, 4ab2, 4ab3 - EcGroEL (mutant) + ATP – Cryo EM
1sx3 - EcGroEL + ATP
1sx4 - EcGroEL + ADP
1mnf – EcGroEL + polypeptide
2cgt – EcGroEL + capsid assbly protein GP31 – EM
1dkd - EcGroEL apical domain + polypeptide
Small subunit
3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae
1wnr – TtCPN10 residues 1-94
1p3h, 1hx5 – MtCPN10
1p82, 1p83 - MtCPN10 residues 1-25 - NMR
1egs - GroES residues 19-27 - NMR
Large + small subunit
1svt, 1pcq - EcGroEL + GroES
1pf9, 1aon - EcGroEL + GroES + ADP
2c7c, 2c7d - EcGroEL + GroES – Cryo EM
1gru - EcGroEL + GroES + ATP + ADP – Cryo EM
1we3 – TtCPN60 + CPN10
1wf4 - TtCPN60 + CPN10 + ADP
Group II
3izh, 3izi, 3izj, 3izk, 3izl, 3izm, 3izn, 3los, 3iyf – MmCPN – Methanococcus maripaludis – EM
3kfb, 3kfe, 3kfk – MmCPN
3j02, 3j03 – MmCPN (mutant) – Cryo EM
3ruq - MmCPN + ADP
3rus - MmCPN (mutant) + ADP
3ruw - MmCPN (mutant) + ADP-AlF3
3ruv - MmCPN (mutant) + ATP analog
1q2v, 1q3r – TkCPN α subunit (mutant) – Thermococcus KS-1
1q3q - TkCPN α subunit (mutant) + AMP-PNP
1q3s - TkCPN α subunit (mutant) + ADP
CCT
2xsm – bCPN CCT – bovine
3p9d, 3p9e, 4d8q, 4d8r – CPN CCT - yeast
3iyg - bCPN CCT – Cryo EM
3ktt - bCPN CCT β subunit – Cryo EM
1gml, 1gn1 - CPN CCT γ subunit apical domain – mouse
Hsp33
3m7m, 1hw7 – EcCPN Hsp33 N-terminal
1xjh - EcCPN Hsp33 C terminal - NMR
1vq0 - CPN Hsp33 – Thermotoga maritima
1vzy - CPN Hsp33 (mutant) – Bacillus subtilis
Thermosome
1a6d - TaTherm α+β subunits – Thermoplasma acidophilum
1a6e - TaTherm α+β subunits + ADP
1ass, 1asx - TaTherm α apical domain
1e0r – TaTherm β apical domain
3ko1 – Therm – Acidianus tengchongensis
3aq1 – Therm – Methanococcoides burtonii
1lep – CPN-10 – Mycobacterium leprae
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Eric Martz, Jaime Prilusky
