Tyrosine kinase

From Proteopedia

Revision as of 16:05, 3 October 2013

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Tyrosine kinase (TK) transfers a phosphate group from ATP to tyrosine residues of proteins. Mutated TK can cause unregulated growth of the cell and their inhibitors can be effective cancer treatment.
For Abelson tyrosine kinase see:

• Bcr-Abl and Imatinib (STI571 or Gleevec).
  

For Src tyrosine kinase see:

• SRC
  
• User:Joseph Lipsick/SRC
  
• Proto-oncogene tyrosine-protein kinase
  

See also Tyrosine Kinase Inhibitor Pharmacokinetics. For references see Treatments:TYKI References.

3D structures of tyrosine kinase

Updated on 03-October-2013

Fyn tyrosine kinase

1shf – hTK Fyn SH3 domain – human
3h0f, 3h0h, 3h0i - hTK Fyn SH3 domain (mutant)

Fyn complex

1fyn - hTK Fyn SH3 domain + peptide
1efn, 1avz - hTK Fyn SH3 domain + HIV Nef protein
1aot, 1aou - hTK Fyn SH2 domain + phosphopeptide - NMR

Abelson tyrosine kinase

Abl SH2 domain

1ab2, 2ecd - hTK abl SH2 domain – NMR
3egu, 3eg2, 3eg3, 3eg0, 3eg1 - hTK abl SH2 domain (mutant)
1abq - mTK abl SH2 domain - mouse
1abo - mTK abl SH2 domain + peptide
3uyo, 3t04, 3k2m - hTK abl SH2 domain + monobody

Abl SH3 domain

1ju5 - hTK abl SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR
1awo - hTK abl SH3 domain + phosphopeptide – NMR
1bbz - hTK abl SH3 domain + peptide
2o88 - hTK abl SH3 domain (mutant} + peptide

Abl SH3-SH2 domain

2abl - hTK abl SH3-SH2 domain
2fo0 - hTK abl SH3-SH2 domain (mutant)

Abl kinase domain

2g2h - hTK abl kinase domain (mutant)
2g1t - hTK abl kinase domain + peptide
2g2i, 2f2f - hTK abl kinase domain (mutant) + peptide
3gvu - hTK abl kinase domain + Gleevec
3ue4, 3cs9, 2hzi, 2hz4, 2hz0, 2hyy, 2gqg - hTK abl kinase domain + cancer drug
2f4j - hTK abl kinase domain (mutant) + cancer drug
3hmi, 3qrk, 3qri, 3qrj, 2v7a, 2e2b, 2hiw - hTK abl kinase domain + inhibitor

Abl SH3-SH2-kinase domain

1opl - hTK abl SH3-SH2-kinase domain (mutant}

Abl C-terminal

2kk1 – hTK abl C terminal – NMR

Bruton’s tyrosine kinase

2z0p - hTK Btk PH domain
1btk – hTK Btk PH domain (mutant)
3p08 - hTK Btk kinase domain
1aww, 1awx, 1qly - hTK Btk SH3 domain – NMR
2ge9 - hTK Btk SH2 domain – NMR

Btk complex

1b55 - hTK Btk PH domain + inositol-tetrakisphosphate
1bwn - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate
3gen, 3ocs, 3pix, 3piy, 3piz, 3pj1, 3pj2, 3pj3 - hTK Btk kinase domain + inhibitor
3k54, 3t9t - hTK Btk kinase domain (mutant) + inhibitor
3oct - hTK Btk kinase domain (mutant) + dasatinib

p55-blk tyrosine kinase

1blj, 1blk - mTK p55-blk SH2 domain – NMR

Src tyrosine kinase

Src tyrosine kinase SH2 domain

4f59 - hTK (mutant)
1f2f - cTK (mutant)
1spr - RsvTK + phosphate – Rous sarcoma virus
1kc2 - RsvTK + peptide
1shd - cTK + TRKA receptor
4f5b - hTK (mutant) + phosphotyrosine
4f5a - hTK (mutant) + phosphate
1o4c - hTK + phosphate
1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49 1o4a, 1o4b, 1o4d 1o4e, 1o4f, 1o4g 1o4h, 1o4i, 1o4j 1o4k, 1o4l, 1o4m 1o4n, 1o4o, 1o4p 1o4q, 1o4r - hTK + inhibitor
1hcs, 1hct - hTK + peptide - NMR
1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e - hTK + peptide
1f1w - cTK (mutant) + peptide
1p13 - cTK + peptide

Src tyrosine kinase SH3 domain

1srl, 1srm - cTK – chicken – NMR
3fj5 - cTK
4hxj, 1prl - cTK + peptide
1prm, 1rlp, 1rlq, 1nlo, 1nlp - cTK + peptide - NMR
4hvu, 4hvv, 4hvw - cTK (mutant) + peptide

Src tyrosine kinase kinase domain

3of0, 2qi8 - cTK (mutant)
1yoj - hTK (mutant)
3tz7, 3tz8, 3tz9, 4dgg – cTK (mutant) + pyrazolin derivative
4fic, 3uqg, 3uqf, 3u51, 3u4w, 4agw, 3qlg, 3qlf, 3g6g, 3el8, 3f6x, 2hwo, 2hwp, 2oiq, 3en4, 3en5, 3en6, 3en7, 3el7 – cTK + inhibitor
4lgg, 4lgh, 3svv, 3oez, 3lok, 3g5d, 3f3w, 3f3v, 3geq, 3g6h, 3f3t, 3f3u, 2qlq, 2qq7, 4lgg, 4lgh – cTK (mutant) + inhibitor
1yol, 1yom – hTK (mutant) + inhibitor
2bdf, 2bdj – hTK + inhibitor
3d7t, 3d7u – cTK + Csk
3dqw, 3dqx - cTK (mutant) + ATP

Src tyrosine kinase C terminal domain

1yi6 - hTK

Src tyrosine kinase SH2+SH3+kinase domains

1ksw – hTK (mutant)+ ADP derivative

Src tyrosine kinase SH2+SH3+kinase+C terminal domains

1fmk – hTK
2ptk – cTK
2src – hTK + AMPPNP

Src tyrosine kinase N terminal+SH2+SH3+kinase domains

2h8h – hTK + inhibitor

Lymphocyte-specific tyrosine kinase Lck

1kik, 1h92 - hTK Lck SH3 domain – NMR
2iim - hTK Lck SH3 domain
4d8k, 1x27 - hTK Lck SH3-SH2 domain
3lck - hTK Lck kinase domain

Lck complex

1lcj, 1lkk, 1lkl - hTK Lck SH2 domain (mutant) + phosphopeptide
1cwd, 1cwe, 1ijr - hTK Lck SH2 domain + phosphopeptide
1bhf - hTK Lck SH2 domain + peptide inhibitor
1fbz - hTK Lck SH2 domain + inhibitor
1bhh - hTK Lck SH2 domain + T-lymphocyte-specific TK
1lck - hTK Lck SH3-SH2 domain (mutant) + phosphopeptide
1x27 - hTK Lck SH3-SH2 domain + peptide
1qpj - hTK Lck kinase domain + staurosporin
2of2, 2of4, 2ofu, 2ofv, 2og8, 3b2w, 3bym, 3bys, 3byu, 2zm1, 2zm4, 3byo, 2zyb, 3ac1, 3ac2, 3ac3, 3ac4, 3ac5, 3ac8, 3acj, 3ack, 3kmm, 3ad4, 3ad5, 3ad6, 1qpc, 1qpd, 1qpe - hTK Lck kinase domain + inhibitor
3mpm - hTK Lck kinase domain (mutant) + inhibitor
2pl0 - hTK Lck kinase domain + imatinib
3kxz - hTK Lck kinase domain + probe molecule

Syk - spleen tyrosine kinase

1xba – Syk kinase domain

Syk complex

1xbb - Syk kinase domain + Gleevec
1xbc - Syk kinase domain + staurosporin
3emg, 3fqe, 3fqh, 3fqs, 3srv, 4dfl, 4dfn, 3vf8, 3vf9, 3tub, 3tuc, 3tud, 4f4p, 4fyn, 4fyo, 4fz6, 4fz7, 4gfg - Syk kinase domain + inhibitor
1csy, 1csz - Syk SH2 domain + phosphopeptide – NMR
4fl1, 4fl2 - Syk kinase domain + ANP
4fl3 - Syk kinase domain (mutant) + ANP
1a81 – Syk tandem SH2 domain + T-cell surface peptide

Fms tyrosine kinase

2i0v - hTK Fms kinase domain

Fms complex

2i0y, 2i1m - hTK Fms kinase domain + inhibitor
3dpk - hTK Fms kinase domain (mutant) + inhibitor
1flt – hTK Fms Igg-like domain + VEGF
1qty - hTK Fms domain 2 + VEGF

Itk tyrosine kinase

1lui, 1luk, 1lum, 1lun – mTK Itk SH2 domain – NMR
3s9k – mTK Itk SH2 domain
2etz, 2eu0 – hTK Itk SH2 domain + phosphopeptide – NMR
1awj, 2rn8, 2rna – mTK Itk SH3 domain – NMR
2yuq, 2lmj – hTK Itk SH3 domain – NMR
2k79, 2k7a – mTK Itk SH2+SH3 domains – NMR
1sm2, 1snu, 1snx – hTK Itk kinase domain
3miy – hTK Itk kinase domain + cancer drug
3v5j, 3v5l, 3v8t, 3v8w – hTK Itk kinase domain + inhibitor
3mj1, 3mj2, 3qgw, 3qgy, 4hct, 4hcu, 4hcv, 4kio – hTK Itk kinase domain (mutant) + inhibitor
3t9t – hTK Itk kinase domain (mutant) + arthritis drug
2e6i – hTK Itk BTK motif – NMR

Zap tyrosine kinase

2ozo - hTK Zap (mutant)
1m61 - hTK Zap SH2 domain

Zap complex

2oq1 - hTK Zap SH2 domain + peptide
1u59 - hTK Zap catalytic domain + staurosporin

Mer tyrosine kinase

2dbj - hTK Mer FN2 domain – NMR
2p0c - hTK Mer catalytic domain

Mer complex

3brb - hTK Mer catalytic domain + ADP
3bpr - hTK Mer catalytic domain + inhibitor

Bone marrow tyrosine kinase

2ekx - hTK Bmx SH2 domain – NMR
2ys2 - hTK Bmx Btk motif – NMR

Bmx complex

3sxr - hTK Bmx kinase domain (mutant) + dasatinib
3sxs - hTK Bmx kinase domain (mutant) + inhibitor

2β tyrosine kinase

3cc6, 3fzo - hTK Pyk2 kinase domain
3gm2 - hTK Pyk2 FAT domain
3gm3 - hTK Pyk2 FAT domain (mutant)

Pyk2 complex

3fzp - hTK Pyk2 kinase domain + ATPγS
3fzr, 3fzs, 3fzt, 3h3c, 3et7 - hTK Pyk2 kinase domain + inhibitor
3gm1 - hTK Pyk2 FAT domain + paxillin peptide

CapAB tyrosine kinase

3bfv - SaTK CapA1/CapB2 – Staphylococcus aureus
2ved - SaTK CapA1/CapB2 + Mg + ADP

Fer tyrosine kinase

2kk6 - hTK Fer SH2 domain – NMR

HCK tyrosine kinase

3hck - hTK SH2 domain - NMR
1bu1 - hTK SH3 domain
4hck, 5hck - hTK SH3 domain - NMR
2oj2, 2oi3 - hTK SH3 domain + peptide - NMR
3rbb, 3rea, 3reb - hTK SH3 domain (mutant) + HIV NEF
3nhn - hTK SH3-SH2-linker domain
2c0i, 2c0o, 2c0t - hTK SH3-SH2-SH1 domain + inhibitor
2hk5 - hTK kinase domain + inhibitor
1qcf, 3vry, 3vrz, 3vs0, 3vs1, 3vs2, 3vs3, 3vs4, 3vs5, 3vs6, 3vs7 - hTK SH3-SH2-kinase-tail domain + inhibitor
1ad5 - hTK SH3-SH2-kinase-tail domain + AMPPNP
2hck - hTK SH3-SH2-kinase-tail domain + quercetin