3jw3
From Proteopedia
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| - | [[Image:3jw3.png|left|200px]] | ||
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{{STRUCTURE_3jw3| PDB=3jw3 | SCENE= }} | {{STRUCTURE_3jw3| PDB=3jw3 | SCENE= }} | ||
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===Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim=== | ===Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/Q81R22_BACAN Q81R22_BACAN]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3jw3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3jw3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JW3 OCA]. |
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:020882962</ref><references group="xtra"/> | + | <ref group="xtra">PMID:020882962</ref><references group="xtra"/><references/> |
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[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Anderson, A C.]] | [[Category: Anderson, A C.]] | ||
[[Category: Beierlein, J M.]] | [[Category: Beierlein, J M.]] | ||
[[Category: Karri, N G.]] | [[Category: Karri, N G.]] | ||
| - | [[Category: Oxidoreductase]] | + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] |
Revision as of 11:46, 20 November 2013
Contents |
Crystal structure of Bacillus anthracis (F96I) dihydrofolate reductase complexed with NADPH and Trimethoprim
Function
[Q81R22_BACAN] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
About this Structure
3jw3 is a 2 chain structure with sequence from "bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946. Full crystallographic information is available from OCA.
See Also
Reference
- Beierlein JM, Karri NG, Anderson AC. Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure-activity relationships. J Med Chem. 2010 Oct 28;53(20):7327-36. PMID:20882962 doi:10.1021/jm100727t
