This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3fy8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3fy8.png|left|200px]]
 
- 
{{STRUCTURE_3fy8| PDB=3fy8 | SCENE= }}
{{STRUCTURE_3fy8| PDB=3fy8 | SCENE= }}
- 
===Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101===
===Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101===
 +
{{ABSTRACT_PUBMED_19622858}}
-
{{ABSTRACT_PUBMED_19622858}}
+
==Function==
 +
[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
==About this Structure==
==About this Structure==
-
[[3fy8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FY8 OCA].
+
[[3fy8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FY8 OCA].
==See Also==
==See Also==
Line 14: Line 13:
==Reference==
==Reference==
-
<ref group="xtra">PMID:019622858</ref><references group="xtra"/>
+
<ref group="xtra">PMID:019622858</ref><references group="xtra"/><references/>
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
-
[[Category: Staphylococcus aureus]]
 
[[Category: Dale, G E.]]
[[Category: Dale, G E.]]
[[Category: Oefner, C.]]
[[Category: Oefner, C.]]

Revision as of 12:16, 20 November 2013

Template:STRUCTURE 3fy8

Contents

Crystal Structure of Staph. aureus DHFR complexed with NADPH and AR-101

Template:ABSTRACT PUBMED 19622858

Function

[DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

3fy8 is a 1 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885. Full crystallographic information is available from OCA.

See Also

Reference

  • Oefner C, Parisi S, Schulz H, Lociuro S, Dale GE. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):751-7. Epub 2009, Jul 10. PMID:19622858 doi:10.1107/S0907444909013936

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fy8"
Personal tools