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Complexin

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{{STRUCTURE_3rk3| PDB=3rk3 | SIZE=400| SCENE= |right|CAPTION=Human complexin complex with SNARE, [[3rk3]] }}
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{{STRUCTURE_3rk3| PDB=3rk3 | SIZE=400| SCENE= |right|CAPTION=Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }}

Revision as of 11:47, 5 December 2013

Template:STRUCTURE 3rk3


Complexin (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.

Contents

3D structures of complexin

Updated on 05-December-2013

1kil – CPLX + SNARE – rat

3rk3, 3rl0 - CPLX + SNARE – human

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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