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Cell death protein
From Proteopedia
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| - | '''Cell death proteins''' (CED) are involved in the process of cellular apoptosis. For details on CED-4 see [[CED-4 Apoptosome]]. | + | '''Cell death proteins''' or '''Programmed cell death protein''' (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. For details on CED-4 see [[CED-4 Apoptosome]]. |
==3D structures of cell death protein== | ==3D structures of cell death protein== | ||
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===CED-1=== | ===CED-1=== | ||
| - | [[ | + | [[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br /> |
| - | [[ | + | [[3rrq] - hCED-1 extracellular domain (mutant) - human<br /> |
| - | [[ | + | [[2m2d] - hCED-1 extracellular domain - NMR<br /> |
| - | [[ | + | [[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br /> |
| - | [[ | + | [[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br /> |
| - | [[ | + | [[3rnq]] - mCED-1 extracellular domain + mCED-L2 extracellular domain<br /> |
| + | [[3bp5]], [[3bp6]] - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain<br /> | ||
| + | [[3rnk]] - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain<br /> | ||
===CED-2=== | ===CED-2=== | ||
Revision as of 10:39, 16 December 2013
Cell death proteins or Programmed cell death protein (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. For details on CED-4 see CED-4 Apoptosome.
3D structures of cell death protein
Updated on 16-December-2013
CED-1
1npu – mCED-1 extracellular domain (mutant) - mouse
[[3rrq] - hCED-1 extracellular domain (mutant) - human
[[2m2d] - hCED-1 extracellular domain - NMR
3bik - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain
3sbw - mCED-1 extracellular domain + hCED-L1 extracellular domain
3rnq - mCED-1 extracellular domain + mCED-L2 extracellular domain
3bp5, 3bp6 - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain
3rnk - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain
CED-2
3qwx, 3qwy - CeCED-2 – Caenorhabditis elegans
CED-4
2a5y - CeCED-4 + CeCED-9
3lqq, 3lqr - CeCED-4
2ggf – hCED-4 MA3 domain – NMR
2rg8, 2kzt - hCED-4 MA3 domain
2iol, 2ion, 2ios, 2nsz - mCED-4 MA3 domain
2hm8 - mCED-4 MA3 domain – NMR
3eij - hCED-4 residues 157-469
2zu6, 3eiq - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I
CED-5
1yyb - hCED-5 N terminal – NMR
2cru, 2k6b - hCED-5 – NMR
CED-6
1y1x - CED-6 – Leishmania major
CED-9
1ohu – CeCED-9
1ty4 - CeCED-9 + programmed CED activator
CED-10
3ajm - hCED-10 + inositol tetrakisphosphate
