Deoxycytidine kinase
From Proteopedia
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[[Image:1p62.png|left|200px|thumb|Crystal structure of human deoxycytidine kinase complex with ADP and chemotherapy agent [[1p62]]]] | [[Image:1p62.png|left|200px|thumb|Crystal structure of human deoxycytidine kinase complex with ADP and chemotherapy agent [[1p62]]]] | ||
| - | {{STRUCTURE_1p62| PDB=1p62 | SIZE=350| SCENE= |right|CAPTION= Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine and Ca+2 ion [[1p62]] }} | + | {{STRUCTURE_1p62| PDB=1p62 | SIZE=350| SCENE= |right|CAPTION= Human deoxycytidine kinase complex with ADP, chemotherapy agent gemcitabine (stick models) and Ca+2 ion (green) [[1p62]] }} |
Revision as of 10:32, 25 December 2013
Deoxycytidine kinase (DCK) is required for the phosphorylation of deoxyribonucleosides dC, dG and dA and nucleosides analogs which are used as antiviral and chemotherapeutic agents. Deficiency of DCK causes resistance to these agents.
Contents |
3D Structures of deoxycytidine kinase
Updated on 25-December-2013
dCK complex with chemotherapy agent
1p5z, 1p62, 2a7q – hDCK + ADP + chemotherapy agent – human
2no9, 2noa, 2no0, 2no6, 2zi9 – hDCK (mutant) + ADP + chemotherapy agent
2zia – hDCK (mutant) + UDP + chemotherapy agent
dCK complex with nucleoside
1p60, 1p61, 3kfx – hDCK + ADP + dC
2no1, 2no7 – hDCK (mutant) + ADP + dC
2zi3, 2zi4 – hDCK (mutant) + ADP + dA
3hp1 – hDCK (mutant) + ADP + dT
2zi5, 2zi6 – hDCK (mutant) + UDP + dA
2zi7 – hDCK (mutant) + UDP + dG
2a2z, 3qen – hDCK (mutant) + UDP + dC
3qeo – hDCK (mutant) + UDP + dT
2a30 – hDCK (mutant) + dC
Other dCK complexes
2qrn – hDCK + UDP + CMP
2qro – hDCK + UDP + AMP
3ipx – hDCK + ADP + inbhibitor
3ipy – hDCK + inbhibitor
3qej – hDCK (mutant) + UDP
3mjr – hDCK + UDP + hydroxyethoxymethylguanine
