Sulfotransferase

From Proteopedia

(Difference between revisions)

Revision as of 10:02, 20 August 2014

Sulfotransferase (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system. The various human STs are named SULT### and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).

3D structures of sulfotransferase

Updated on 20-August-2014

Estrogen ST

1aqy – mST + PAP – mouse
1aqu – mST + estradiol + PAP
1bo6 - mST + VO4 + PAP
1hy3 - hST (mutant) + PAP – human
4jvl - hST (mutant) + estradiol + PAP
4jvm, 4jvn - hST (mutant) + flame retardant + PAP

1g3m - hST + tetrachloro-biphenyl-diol + PAP

Arylsulfate ST

3elq - EcST – Escherichia coli
4p04, 4p07 – EcST (mutant)
3ets – EcST + methylumbelliferone
4p06 - EcST (mutant) + methylumbelliferone
3ett - EcST + p-nitrophenol + sulfate
4p05 – EcST (mutant) + nitrophenylsulfate

Hydroxysteroid ST

1efh - hST + PAP

Alcohol ST

1j99 - hST + androsterone derivative
1ov4 - hST (mutant) + androsterone derivative

Pregnenolone ST

1q1q - hST + PAP

Cholesterol ST

1q1z - hST + PAP
1q20, 1q22 - hST + cholesterol derivative + PAP

Heparan sulfate ST

1vkj - mST (mutant) + PAP
1t8t - hST catalytic domain + PAP
3f5f – ST/MBP + PAP - chicken

Heparan sulfate glucosamine 3-o-ST

1zrh - hST + PAP
3bd9 - hST (mutant) + PAP
1t8u - hST catalytic domain + tetrasaccharide + PAP
3uan - mST + pentasaccharide + PAP

Tyrosine-ester ST

2zpt, 2zyt - mST + PAP
2zvp, 2zyv, 2zyw - mST + p-nitrophenol + PAP
2zyu - mST + p-nitrophenyl sulfate + PAP
2zvq - mST + α-naphthol + PAP

Tyrosylprotein ST

3ap1, 3ap2 - hST + peptide + PAP
3ap3 - hST + PAP

SULT1C2

2ad1 – hST
3bfx - hST (mutant) + PAP
2gwh - hST + pentachlorophenol + PAP

SULT1C3

2h8k - hST + PAP

SULT4A1

1zd1 – hST

SULT1A3

2a3r – hST + dopamine + PAP
1cjm - hST + sulfate

SULT1A1

3u3j, 4gra - hST + PAP
2d06 – hST + estradiol + PAP
3qvu, 3u3r – hST (mutant) + p-nitrophenol + PAP
3qvv - hST (mutant) + hydroxyl-chromene-carbonitrile + PAP
1ls6 - hST + p-nitrophenol + PAP
3u3k - hST + 3-naphthol + PAP
3u3m, 3u3o - hST + 3-cyano-7-hydroxycoumarin + PAP

SULT1A2

1z28, 1z29 - hST + hydroxyl-acetylamino fluorine

SULT1B1

2z5f - hST + PAP
3ckl - hST + resveratrol + PAP

SULT2A1

2qp3, 2qp4 - hST (mutant) + aetiocholanolone
3f3y - hST + lithocholic acid + PAP
4ifb - hST (mutant) + PAP

STF0 ST

1tex, 2zq5 - ST – Mycobacterium smegmatis

3rnl - ST – Alicyclobacillus acidocaldarius
4mua – SmST – Schistosoma mansoni
4mub – SmST + oxamniquine

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Sulfotransferase"

Category: Topic Page

@@ Line 12: / Line 12: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-'''Estrogen ST '''
+===Estrogen ST ===
 [[1aqy]] – mST + PAP – mouse<BR />
@@ Line 23: / Line 23: @@
 [[1g3m]] - hST + tetrachloro-biphenyl-diol + PAP<BR />
-'''Arylsulfate ST '''
+===Arylsulfate ST ===
 [[3elq]] - EcST – ''Escherichia coli''<BR />
@@ Line 32: / Line 32: @@
 [[4p05]] – EcST (mutant) + nitrophenylsulfate <br />
-'''Hydroxysteroid ST '''
+===Hydroxysteroid ST ===
 [[1efh]] - hST + PAP<BR />
-'''Alcohol ST'''
+===Alcohol ST===
 [[1j99]] - hST + androsterone derivative<BR />
 [[1ov4]] - hST (mutant) + androsterone derivative
-'''Pregnenolone ST'''
+===Pregnenolone ST===
 [[1q1q]] - hST + PAP<BR />
-'''Cholesterol ST'''
+===Cholesterol ST===
 [[1q1z]] - hST + PAP<BR />
 [[1q20]], [[1q22]] - hST + cholesterol derivative + PAP<BR />
-'''Heparan sulfate ST '''
+===Heparan sulfate ST ===
 [[1vkj]] - mST (mutant) + PAP<BR />
@@ Line 56: / Line 56: @@
 [[3f5f]] – ST/MBP + PAP - chicken
-'''Heparan sulfate glucosamine 3-o-ST'''
+===Heparan sulfate glucosamine 3-o-ST===
 [[1zrh]] - hST + PAP<BR />
@@ Line 63: / Line 63: @@
 [[3uan]] - mST + pentasaccharide + PAP<BR />
-'''Tyrosine-ester ST'''
+===Tyrosine-ester ST===
 [[2zpt]], [[2zyt]] - mST + PAP<BR />
@@ Line 70: / Line 70: @@
 [[2zvq]] - mST + α-naphthol + PAP<BR />
-'''Tyrosylprotein ST '''
+===Tyrosylprotein ST ===
 [[3ap1]], [[3ap2]] - hST + peptide + PAP<BR />
 [[3ap3]] - hST + PAP<BR />
-'''SULT1C2'''
+===SULT1C2===
 [[2ad1]] – hST<br />
@@ Line 81: / Line 81: @@
 [[2gwh]] - hST + pentachlorophenol + PAP<BR />
-'''SULT1C3'''
+===SULT1C3===
 [[2h8k]] - hST + PAP<br />
-'''SULT4A1'''
+===SULT4A1===
 [[1zd1]] – hST
-'''SULT1A3'''
+===SULT1A3===
 [[2a3r]] – hST + dopamine + PAP<BR />
 [[1cjm]] - hST + sulfate
-'''SULT1A1'''
+===SULT1A1===
 [[3u3j]], [[4gra]] - hST + PAP<BR />
@@ Line 104: / Line 104: @@
 [[3u3m]], [[3u3o]] - hST + 3-cyano-7-hydroxycoumarin + PAP<BR />
-'''SULT1A2'''
+===SULT1A2===
 [[1z28]], [[1z29]] - hST + hydroxyl-acetylamino fluorine
-'''SULT1B1'''
+===SULT1B1===
 [[2z5f]] - hST + PAP<BR />
 [[3ckl]] - hST + resveratrol + PAP<BR />
-'''SULT2A1'''
+===SULT2A1===
 [[2qp3]], [[2qp4]] - hST (mutant) + aetiocholanolone<BR />
@@ Line 119: / Line 119: @@
 [[4ifb]] - hST (mutant) + PAP<br />
-'''STF0 ST'''
+===STF0 ST===
 [[1tex]], [[2zq5]] - ST – ''Mycobacterium smegmatis''