Platelet glycoprotein
From Proteopedia
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[[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) – human <BR /> | [[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) – human <BR /> | ||
Revision as of 10:00, 23 September 2014
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Contents |
Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain
Transient interactions of platelet-receptor glycoprotein Ibalpha (GpIbalpha) and the plasma protein von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a role in haemostasis and thrombosis. Here we present structures of the GpIbalpha amino-terminal domain and its complex with the VWF domain A1. In the complex, GpIbalpha wraps around one side of A1, providing two contact areas bridged by an area of solvated charge interaction. The structures explain the effects of gain-of-function mutations related to bleeding disorders and provide a model for shear-induced activation. These detailed insights into the initial interactions in platelet adhesion are relevant to the development of antithrombotic drugs.
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain., Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P, Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Disease
Known disease associated with this structure: von Willebrand disease, autosomal dominant OMIM:[193400], von Willebrand disease, autosomal recessive OMIM:[193400], Bernard-Soulier syndrome, benign autosomal dominant OMIM:[606672], Bernard-Soulier syndrome, type A OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672]
About this Structure
1m10 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
3D structures of platelet glycoprotein Ib
Updated on 23-September-2014
Platelet glycoprotein Ib
1m0z – hPGIb von Willenbrand factor binding domain (mutant) – human
1gwb, 1p9a, 1qyy – hPGIb N terminal domain
Platelet glycoprotein Ib complexes
1m10, 1sq0 – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)
1u0n – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin
1gwb – hPGIb N terminal domain (mutant) + α thrombin
1p8v – hPGIb von Willenbrand factor binding domain (mutant) + prothrombin
3pmh – hPGIb von Willenbrand factor binding domain (mutant) + thrombin
2bp3 – hPGIb cytoplasmic domain + filamin A rod domain
1sq0 – hPGIb von Willenbrand factor binding domain + peptide inhibitor
Reference
- Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630 doi:10.1126/science.107355
See Also
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, Jaime Prilusky
